摘要
2-吡喃酮衍生物在药物领域表现出了巨大的应用潜力,已有很多该类骨架结构用作合成药物活性分子前体.因此,探索新型2-吡喃酮衍生物的合成方法非常重要.以β-酮酰胺衍生物和氰基乙酸乙酯为原料一步反应合成了2-吡喃酮衍生物,具有产物收率高(82%~93%)、反应条件温和产物后处理方便等优点,为2-吡喃酮生物的合成提供了新策略.
2-Pyrone derivatives have demonstrated considerable potential for usage in the field of medicine.Many of these skeleton structures have been used as precursors in the synthesis of pharmacologically active molecules.As a result,it is critical to explore new approaches for the synthesis of 2-pyrones.A series of 2-pyrone derivatives were synthesized fromβ-oxo amides and ethyl cyanoacetate through one-step reaction.The methodology offers several significant advantages including mild conditions,ease of handling,and high yields(82%~93%).Such,an efficient synthesis approach for 2-pyrones is provided.
作者
高宝昌
石雨
田媛
张治国
张婧如
孙宇峰
毛国梁
戴凌燕
Gao Baochang;Shi Yu;Tian Yuan;Zhang Zhiguo;Zhang Jingru;Sun Yufeng;Mao Guoliang;Dai Lingyan(College of Chemistry and Chemical Engineering,Northeast Petroleum University,Daqing,Heilongjiang 163319;Institute of Phytochemistry,Daqing Branch of Heilongjiang Academy of Sciences,Daqing,Heilongjiang 163319;College of Science and Biotechnology,Heilongjiang Bayi Agricultural University,Daqing,Heilongjiang 163319)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2024年第2期644-649,共6页
Chinese Journal of Organic Chemistry
基金
黑龙江省自然科学基金(No.LH2020B022)
黑龙江省科学院院长基金(No.YZ2022DQ01)
黑龙江省科学院双提雁阵特别计划基金(No.YZQY2023DQ01)
黑龙江省省属科研院所科研业务费基金(No.YS2023DQ02)资助项目.
