摘要
非酒精性脂肪肝病(non-Alcoholic fatty liver disease, NAFLD)作为慢性肝病最主要的患病原因,已经对全球的公共健康卫生与医疗带来了巨大挑战。由于NAFLD的发病机制尚不明确,脂质积累在NAFLD疾病发展中起到关键作用。AMP依赖的蛋白激酶(AMPK)作为脂质代谢调节关键分子,能够改善NAFLD所造成的脂质积累。本文阐述了AMPK相关分子改善脂质积累并治疗NAFLD的具体作用机制,同时列举了目前AMPK相关实验和治疗研究的药物。证明了AMPK相关药物用于改善脂肪积累、治疗NAFLD的潜力,为后续对于AMPK相关治疗NAFLD药物的研究提供了思路与参考。
Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease and has posed significant challenges to global public health and medical care.Due to the unclear pathogenesis of NAFLD,lipid accumulation plays a key role in its development.AMPK,as a crucial molecule in lipid metabolism regulation,can improve lipid accumulation caused by NAFLD.This article describes the specific mechanisms of AMPK-related molecules in improving lipid accumulation and treating NAFLD,and lists the current experimental and therapeutic drugs related to AMPK.The potential of AMPK-related drugs in improving lipid accumulation and treating NAFLD is demonstrated,providing ideas and references for future research on AMPK-related drugs for treating NAFLD.
作者
孙鹏帅
朱峰
郑丽红
王海强
SUN Pengshuai;ZHU Feng;ZHENG Lihong;WANG Haiqiang(The First Clinical Medical College of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第6期862-866,共5页
The Journal of Practical Medicine
基金
国家中医药管理局基金资助项目(编号:国中医药人教函[2022]1号)
黑龙江省中医药科研基金项目(编号:ZHY2023-125)
黑龙江中医药大学“优秀青年骨干教师”计划(编号:15041190018)。
关键词
非酒精性脂肪肝病
AMPK
脂质代谢
临床治疗
non-alcoholic fatty liver disease
AMPK
lipid metabolism
clinical treatment
