摘要
卟啉广泛存在于自然界,因其优异的光物理和电化学性能而备受关注.然而,卟啉的不稳定性、自猝灭和水溶性差等固有缺陷限制了它在生物学领域的应用.近年来,在金属有机框架(MOFs)中引入卟啉分子或利用卟啉作为有机连接剂构建卟啉金属有机框架(PMOFs)成为研究焦点.PMOFs既可以克服卟啉的局限性,又兼具卟啉与MOFs各自的独特性.文章通过改变反应条件,合成了3种不同形貌特征的锆基卟啉金属有机框架PCN-224,这种材料不仅保持了卟啉在红光照射下产生单线态氧(^(1)O_(2))的特点,还可作为药物载体,为PMOFs的结构调控和生物学应用提供了新思路.
Porphyrins are ubiquitous in nature and are of great interest due to their excellent photophysical and electrochemical properties.However,intrinsic defects of porphyrins,such as instabilities,self-quenching,and poor water solubility,limit its biological applications.In recent years,researchers have focused on incorporating porphyrins into metal-organic frameworks(MOFs)or using them as organic linkers to create porphyrinic metal-organic frameworks(PMOFs).PMOFs can not only overcome the limitations of porphyrins,but also combine the unique properties of porphyrins and MOFs.In this work,three zirconium-based porphyrin metal-organic frameworks PCN-224 with different morphological features were synthesized by varying the reaction conditions.These MOFs not only maintain the characteristic of porphyrin producing singlet oxygen(^(1)O_(2))under red light irradiation,but also serves as drug carriers,providing new ideas for the structural regulation and biological applications of PMOFs.
作者
彭龙漩
张凤娟
黄艳
陈楠
吕敏
PENG Longxuan;ZHANG Fengjuan;HUANG Yan;CHEN Nan;LYU Min(College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China)
基金
国家自然科学基金(31971310,32371439)。
