摘要
目的 研究信迪利单抗注射液辅助化疗治疗非小细胞肺癌对血清肿瘤标志物和外周血Th17/Treg的影响。方法 选取天长市中医院肿瘤二科2020年1月至2023年1月收治的60例非小细胞肺癌患者,采用随机数字表法将患者分为接受常规化疗的对照组(30例)与接受信迪利单抗注射液辅助化疗治疗的观察组(30例)。比较两组疗效、血清肿瘤标志物、外周血Th17、Treg细胞水平以及毒副反应。结果 观察组总有效率高于对照组,差异有统计学意义(t=4.286,P<0.05)。治疗后两组癌胚抗原(CEA)、糖类抗原125(CA125)以及细胞角蛋白19片段抗原(CYFRA21-1)水平均显著低于治疗前,且治疗后观察组CEA、CA125及CYFRA21-1水平均显著低于对照组,差异有统计学意义(t=6.042、25.734、7.842,P<0.05)。治疗后两组Th17、Treg水平显著低于治疗前,且治疗后观察组Th17、Treg水平显著低于对照组,差异有统计学意义(t=7.216、4.426,P<0.05)。观察组各项发生率均高于对照组,但其中骨髓抑制、发热、肝功能异常以及腹泻差异均无统计学意义(t=0.659、0.884、1.832、0.480,P>0.05),观察组皮疹发生率显著高于对照组,差异有统计学意义(t=4.800,P<0.05)。结论 采用信迪利单抗注射液辅助化疗治疗非小细胞肺癌效果确切,可调节患者肿瘤标志物以及T淋巴细胞功能,但其毒副反应情况还需进一步研究。
Objective To study the effect of sintilimab injection as adjuvant chemotherapy in the treatment of non-small cell lung cancer on serum tumor markers and peripheral blood Th17/Treg.Methods Sixty patients with non-small cell lung cancer were admitted to the No.2 Department of Oncology at Tian-chang Hospital of Traditional Chinese Medicine from January 2020 to January 2023.They were selected and di-vided into two groups:the control group(30 patients undergoing conventional chemotherapy)and the observa-tion group(30 patients undergoing sintilimab injection as adjuvant chemotherapy)using the random number ta-ble method.The efficacy,serum tumor markers,peripheral blood Th17 and Treg cell levels,and toxicities in the two groups were compared.Results The total effective rate in the observation group was higher than that in the control group,showing a statistically significant difference(t=4.286,P<0.05).Following treatment,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),cytokeratin 19 fragment(CYFRA21-1),Th17 and Treg cells in both groups decreased significantly.The levels in the observation group were notably lower than those in the control group,with statistically significant differences(t=6.042,25.734,7.842,7.216,4.426,P<0.05).The incidence rates of toxicities in the observation group were higher than those in the control group.However,there was no statistically significant difference in the incidence rates of bone marrow suppression,fever,abnormal liver function and diarrhea(t=0.659,0.884,1.832,0.480,P>0.05).The incidence of skin rash in the observation group was significantly higher than that in the control group,indicating a statistically significant difference(t=4.800,P<0.05).Conclusion Sintilimab injection as adjuvant chemotherapy for non-small cell lung cancer is proven to be effective.It can regulate tumor markers and T lymphocyte function,additional research on potential toxicities is necessary.
作者
阮鹏飞
吴生保
刁忆
冯天明
RUAN Pengfei;WU Shengbao;DIAO Yi;FENG Tianming(No.2 Department of Oncology,Tianchang Hospital of Traditional Chinese Medicine,Tianchang,Anhui,China,239300)
出处
《分子诊断与治疗杂志》
2024年第3期425-428,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽中医药大学临床科研项目立项项目(2016tclc003)。
