摘要
TLR7/8是动物体内重要的模式识别受体(pattern recognition receptors,PRRs),启动固有免疫并激活适应性免疫,在病原感染中发挥重要作用。TLR7/8激动剂具有增强机体免疫应答的作用,能够激活免疫细胞,调节炎性细胞因子的产生,对加速病原清除具有重要意义,被认为是许多疾病的潜在防治药物,有希望用于治疗病毒感染、肿瘤等疾病,或作为免疫佐剂为动物机体提供持久的抗体保护。常见的TLR7/8激动剂包括咪唑喹啉类衍生物和核苷类似物等,有些药物已进入临床研究阶段,但仅有少数获批临床。现主要围绕TLR7/8激动剂及其在抗病毒、免疫佐剂等方面的潜在应用进行综述。
TLR7 and 8 are important pattern recognition receptors(PRRs)in animals,which initiate innate immunity and activate adaptive immunity,playing an important role in pathogenic infection.TLR7/8 agonists have the function of enhancing the immune response of the body,activating immune cells,regulating the production of inflammatory cytokines,and are of great significance in accelerating the clearance of pathogens.These ligands are considered to be a potential preventive drug for many diseases and are expected to be used in the treatment of viral infections,tumors and other diseases,or as an immune adjuvant to provide lasting antibody protection for animals.The common TLR7/8 agonists are mostly imidazoquinolines derivatives and nucleoside analogues.Although some drugs have entered the clinical research stage,only a few have been approved for clinical use.In this paper,TLR7/8 agonists and their potential applications in antiviral and immune adjuvants are summarized.
作者
刘畅
李剑勇
LIU Chang;LI Jianyong(Key Laboratory of New Animal Drug Project of Gansu Province/Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture,Lanzhou Institute of Husbandry and Pharmaceutical Science,Chinese Academy Agriculture Sciences,Lanzhou 730050,China)
出处
《中国兽医学报》
CAS
CSCD
北大核心
2024年第1期206-216,共11页
Chinese Journal of Veterinary Science
基金
中国农业科学院科技创新工程资助项目(25-LZIHPS-02)。
关键词
TLR7/8激动剂
免疫增强剂
畜禽疾病防治
抗病毒
免疫佐剂
TLR 7/8 agonists
immunoenhancer
prevention and control of livestock and poultry diseases
antivirus
adjuvant
