摘要
目的:探讨冠心病(CHD)患者血清胱抑素C(CysC)、高敏C反应蛋白(hs-CRP)、非高密度脂蛋白胆固醇(non-HDL-C)与血流储备分数的相关性。方法:选取150例冠心病患者为研究对象,行冠状动脉造影(CAG)检查,以血流储备分数(FFR)为分组标准,FFR>0.75组81例、FFR≤0.75组69例,比较两组患者冠脉造影结果,血清CysC、hs-CRP、non-HDL-C水平,分析血清CysC、hs-CRP、non-HDL-C与FFR值的相关性及FFR值影响因素。结果:FFR≤0.75组管腔狭窄比高于FFR>0.75组及最小管腔直径小于FFR>0.75组(均P<0.05)。FFR≤0.75组血清CysC、hs-CRP、non-HDL-C水平高于FFR>0.75组(均P<0.05)。血清CysC、hs-CRP、non-HDL-C水平与冠心病患者FFR值均呈负相关(均P<0.05)。Gensini总评分、纤维蛋白原(FG)、CysC、hs-CRP、non-HDL-C为影响CHD患者FFR值的危险因素(均P<0.05)。结论:冠心病患者FFR值降低与血清CysC、hs-CRP、non-HDL-C水平密切相关,可为临床初步判断CHD患者是否存在心肌缺血提供依据。
Objective:To investigate the correlation between serum cystatin C(CysC),high-sensitive C-reactive protein(hs-CRP),non-high-density lipoprotein cholesterol(non-HDL-C)and blood flow reserve fraction in patients with coronary heart disease(CHD).Methods:A total of 150 patients with coronary heart disease were selected as the study objects,and CAG examination was performed.Blood flow reserve fraction(FFR)was used as the grouping criterion,with 81 cases in the FFR>0.75 group and 69 cases in the FFR≤0.75 group.Coronary angiography results of the two groups were compared,and serum levels of CysC,hs-CRP and non-HDL-C were compared.The correlation between serum CysC,hs-CRP,non-HDL-C and FFR value and the influencing factors of FFR value were analyzed.Results:The lumen stenosis ratio in FFR≤0.75 group was higher than that in FFR>0.75 group,and the minimum lumen diameter was lower than that in FFR>0.75 group(all P<0.05).Serum levels of CysC,hs-CRP and non-HDL-C in FFR≤0.75 group were higher than those in FFR>0.75 group(all P<0.05).Serum CysC,hs-CRP and non-HDL-C levels were negatively correlated with FFR values in patients with coronary heart disease(all P<0.05).Gensini total score,FG,CysC,hs-CRP and non-HDL-C were risk factors affecting FFR value in CHD patients(all P<0.05).Conclusion:The decrease of FFR value in CHD patients is closely related to the levels of serum CysC,hs-CRP and non-HDL-C,which can provide a basis for preliminary clinical judgment of functional ischemia in CHD patients.
作者
梁铖
谢玉霞
王新成
刘文宇
毛岚·吐尔干
武刚
LIANG Cheng;XIE Yuxia;WANG Xincheng;LIU Wenyu;MAOLAN Turkan;WU Gang(Second Department of Cardiology,Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine,Urumqi 830000,China)
出处
《陕西医学杂志》
CAS
2024年第4期500-504,共5页
Shaanxi Medical Journal
基金
新疆维吾尔自治区自然科学基金资助项目(2021D01C221)。
关键词
冠心病
冠状动脉造影
血流储备分数
胱抑素C
高敏C反应蛋白
非高密度脂蛋白胆固醇
Coronary heart disease
Coronary angiography
Blood flow reserve fraction
Cystatin C
High-sensitivity C-reactive protein
Non-high-density lipoprotein cholesterol
