摘要
目的探讨可乐定联合认知行为干预对抽动障碍(Tic disorder,TD)患儿的疗效及对身心的影响。方法选取我院2020年9月~2022年12月期间101例TD患儿作为研究对象,采用随机数字表法分为药物组和综合组。药物组50例给予可乐定透皮贴片外用,综合组51例增加认知行为干预,对比两组抽动症状、依从性、神经功能、焦虑情绪和不良反应。结果综合组干预2月末发声性抽动、运动性抽动、儿童焦虑性情绪障碍筛查表(The Screen for Child Anxiety Related Emotional Disorders,SCARED)、Morisky量表(Morisky Adherence Questionnaire,MAQ)、行为依从性评分水平低于药物组;运动、感觉评分高于药物组(P<0.05)。经Fisher确切概率法检验,综合组不良反应发生率1.96%(1/51)与药物组6.00%(3/50)无显著差异(P>0.05)。结论可乐定联合行为干预可调节TD患儿神经功能及焦虑情绪,改善抽动症状,调节依从性,具有较高安全性。
Objective To investigate the effects of clonidine combined behavioral intervention on compliance,neurological function and anxiety in children with tic disorder(TD).Methods A total of 101 children with TD in our hospital from September 2020 to December 2022 were selected as research objects and divided into drug group and com-prehensive group by random number table method.Fifty cases in the drug group received clonidine transdermal patch for external use,and 51 cases in the comprehensive group received cognitive behavioral intervention.Tic symptoms,compliance,neurological function,anxiety,and adverse reactions were compared between the two groups.Results At the end of the 2-month intervention in the comprehensive group,the screen for Children Anxiety Related Emotional Disorders(SCARED),Morisky Adhesion Questionnaire(MAQ),and behavioral compliance scores were lower than those in the drug group;The motor and sensory scores were higher than those of the drug group(P<0.05).According to Fisher's exact probability test,the incidence of adverse reactions in the comprehensive group was 1.96%(1/51)and the drug group was 6.00%(3/50),and there was no difference(P>0.05).Conclusion Clonidine combined with behavioral intervention can regulate the neurological function and anxiety in children with TD,improve tic symptoms,regulate compliance,and have high safety.
作者
李洁
LI Jie(Department of Pediatrics,Hebi People's Hospital,Hebi 458030,China)
出处
《国际精神病学杂志》
2024年第1期151-154,共4页
Journal Of International Psychiatry
关键词
可乐定
抽动障碍
神经功能
Clonidine
Tic disorder
Neural function
