摘要
目的探讨肺腺癌患者计算机断层扫描(CT)征象表现及与抑癌基因(P53)、上皮钙黏蛋白(E-cadherin)、转化生长因子-β1(TGF-β1)蛋白表达的相关性。方法选择2020年1月至2022年12月在新乡市中心医院行手术切除的97例肺腺癌患者为研究对象,采用免疫组化法检测肺腺癌组织及癌旁组织P53、E-cadherin、TGF-β1蛋白表达情况,术前采用德国西门子64排多层螺旋CT增强扫描,分析CT征象与P53、E-cadherin、TGF-β1蛋白表达的相关性。结果肺腺癌组织P53、TGF-β1蛋白阳性表达率高于癌旁组织,E-cadherin蛋白阳性表达率低于癌旁性组织(P<0.05);有棘突征、毛刺征和分叶征CT征象的肺腺癌组织中P53蛋白阳性表达率高于无棘突征、毛刺征和分叶征CT征象者(P<0.05);有棘突征、毛刺征CT征象的肺腺癌组织中E-cadherin蛋白阳性表达率低于无棘突征、毛刺征CT征象者(P<0.05);有血管集束征、毛刺征、分叶征CT征象的肺腺癌组织中TGF-β1蛋白阳性表达率高于无血管集束征、毛刺征、分叶征CT征象者(P<0.05)。结论肺腺癌组织P53、TGF-β1蛋白表达增高,E-cadherin蛋白表达降低,其阳性表达率与肺腺癌患者CT征象存在一定的相关性。
Objective To explore the the computed tomography(CT)signs of lung adenocarcinoma patients and their correlation with tissue tumor suppressor genes(P53),epithelial cadherin(E-cadherin)and transforming growth factor-β1(TGF-β1).Methods A total of 97 patients with lung adenocarcinoma who were underwent surgical resection in Xinxiang Central Hospital from January 2020 to December 2022 were selected as the research subjects,and the expression of P53,E-cadherin and TGF-β1 protein in lung adenocarcinoma tissues and adjacent tissues was detected by immunohistochemistry,and the correlation between CT signs and P53,E-cadherin and TGF-β1 protein expression was analyzed by Siemens 64-row multilayer helical CT enhancement scan before surgery.Results The positive expression rate of P53 and TGF-β1 protein in lung adenocarcinoma tissues was higher than that in adjacent tissues,and the positive expression rate of E-cadherin was lower than that in paracancerous tissues(P<0.05).The positive expression rate of P53 in lung adenocarcinoma tissues with spike sign,burr sign and lobulation sign CT sign was higher than that without spike sign,burr sign and lobulation sign CT sign(P<0.05).The positive expression rate of E-cadherin in lung adenocarcinoma tissues with spinous signs and burr signs was lower than that without spinous signs and burr signs in CT(P<0.05).The positive expression rate of TGF-β1 in lung adenocarcinoma tissues with vascular bundle sign,burr sign and lobulation sign CT sign was higher than that without vascular bundle sign,burr sign,and lobulated CT sign(P<0.05).Conclusion The expression of P53 and TGF-β1 protein in lung adenocarcinoma tissues is increased,and the expression of E-cadherin is reduced,and the positive expression rate is correlated with CT signs in lung adenocarcinoma patients.
作者
孟锦
孙兴智
范雪微
MENG Jin;SUN Xingzhi;FAN Xuewei(CT Room,Xinxiang Central Hospital/the Fourth Clinical College of Xinxiang Medical University,Xinxiang 453000,China;MRI Room,Xinxiang Central Hospital/the Fourth Clinical College of Xinxiang Medical University,Xinxiang 453000,China)
出处
《河南医学研究》
CAS
2024年第5期925-929,共5页
Henan Medical Research
基金
河南省医学科技攻关计划项目(LHGJ20220999)。
关键词
肺腺癌
计算机断层扫描征象
抑癌基因
上皮钙黏蛋白
转化生长因子-β1
相关性
lung adenocarcinoma
computed tomography signs
tumor suppressor genes
epithelial cadherin
transforming growth factor-β1
correlation
