摘要
目的探讨白蛋白、丙种球蛋白辅助蓝光治疗新生儿高胆红素血症的临床对比。方法选取2018年1月—2022年12月梧州市妇幼保健院收治的65例高胆红素血症新生儿,根据其诊断结果分为丙种球蛋白组33例(诊断新生儿ABO血型不合溶血病引起的高胆红素血症)与白蛋白组32例(未诊断新生儿ABO血型不合溶血病引起的高胆红素血症)。丙种球蛋白组采取丙种球蛋白辅助蓝光进行治疗,白蛋白组采取白蛋白辅助蓝光进行治疗。比较2组临床疗效、血清总胆红素(total bilirubin,TBIL)、间接胆红素(indirect bilirubin,IBIL)、直接胆红素(direct bilirubin,DBIL)水平及不良反应发生率。结果与白蛋白组(84.38%)比较,丙种球蛋白组临床疗效(93.94%)显著升高,差异有统计学意义(P<0.05)。与治疗前比较,治疗后2组血清TBIL、IBIL、DBIL显著降低,丙种球蛋白组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。与白蛋白组(12.50%)比较,丙种球蛋白组治疗期间(6.06%)总发生率显著降低,差异有统计学意义(P<0.05)。结论白蛋白、丙种球蛋白辅助蓝光均可有效治疗新生儿高胆红素血症,但相较于白蛋白,丙种球蛋白辅助蓝光治疗的疗效更为显著,不良反应更少,具有一定的临床参考价值。
Objective To explore the clinical comparison of albumin and gamma globulin assisted blue light treatment of neonatal hyperbilirubinemia.Methods A total of 65 newborns with hyperbilirubinemia admitted to the Wuzhou Maternal and Child Health-Care Hospital from January 2018 to December 2022 were selected.Based on their diagnostic results,they were divided into the immunoglobulin group(33 cases diagnosed with hyperbilirubinemia caused by ABO incompatible hemolytic disease in newborns)and the albumin group(32 cases diagnosed with hyperbilirubinemia caused by ABO incompatible hemolytic disease in newborns),The gamma globulin group received gamma globulin assisted blue light treatment,while the albumin group received albumin assisted blue light treatment.The clinical efficacy of two groups,serum total bilirubin(TBIL),indirect bilirubin(IBIL),and direct bilirubin(DBIL)levels,the incidence of adverse reactions were compared.Results Compared with the albumin group(84.38%),the clinical efficacy of the gamma globulin group(93.94%)was significantly higher than that of the albumin group,and the difference was statistically significant(P<0.05).Compared with before treatment,the serum TBIL,IBIL,DBIL levels of the two groups were significantly decreased after treatment,and the decrease range of the gamma globulin group was significantly greater than that of the control group,and the difference was statistically significant(P<0.05).Compared with the albumin group(12.50%),the incidence of adverse reactions(6.06%)in the globulin group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Albumin and gamma globulin assisted blue light therapy can effectively treat neonatal hyperbilirubinemia,but compared with albumin,gamma globulin assisted blue light therapy has more significant effect and fewer adverse reactions,which has certain clinical reference value.
作者
张飞
刘秋雄
蒋红新
ZHANG Fei;LIU Qiuxiong;JIANG Hongxin(Department of Neonatology,Wuzhou Maternal and Child Health-Care Hospital,Wuzhou Guangxi 543002,China)
出处
《中国卫生标准管理》
2024年第5期32-36,共5页
China Health Standard Management
