摘要
目的总结抗血管生成药产生不良反应的特点,对比中药联合抗血管生成药与抗血管生成药所产生不良反应的情况,为临床安全使用肿瘤抗血管生成药治疗提供参考。方法回顾性分析2022年1月~2023年2月辽宁中医药大学附属医院53例恶性肿瘤患者,所有患者均应用抗血管靶向药物治疗,观察组(28例)使用抗血管生成药联合中药治疗,对照组(25例)使用抗血管生成药治疗。对比两组的不良反应类型及发生率。结果观察组患者不良反应发生率低于对照组(39.3%vs.68.0%)。观察组患者出血、贫血、血小板减少、腹泻、呕吐、蛋白尿、皮疹、手足麻木、口腔溃疡的发病率明显低于对照组。中药对于乏力的治疗有显著的疗效。但观察组与对照组在降低高血压及白细胞减少这两种不良反应的发生率上未见明显差异。结论中药治疗对于缓解抗血管生成靶向药物引起的不良反应有较好的疗效,提高患者生活质量。
Objective To summarize the characteristics of adverse reactions caused by anti-angiogenic drugs,and to compare the adverse reactions caused by traditional Chinese medicine combined with anti-angiogenic drugs and anti-angiogenic drugs,so as to provide reference for the safe use of anti-angiogenic drugs for tumor therapy.Methods A retrospective analysis was performed on 53 patients with malignant tumors in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2022 to February 2023.All patients were treated with anti-vascular targeted drugs.The observation group(28 cases)was treated with anti-angiogenic drugs combined with traditional Chinese medicine,and the control group(25 cases)was treated with anti-angiogenic drugs.The types and incidence of adverse reactions were compared between the two groups.Results The incidence of adverse reactions in the observation group was lower than that in the control group(39.3%vs.68%).The incidence of hemorrhage,anaemia,thrombocytopenia,diarrhea,vomiting,proteinuria,rash,numbness of hands and feet,and oral ulcer in the observation group was significantly lower than that in the control group.Chinese medicine is effective in the treatment of fatigue.However,there was no significant difference between the observation group and the control group in reducing the incidence of hypertension and leukopenia.Conclusion Chinese medicine is effective in relieving the adverse reactions caused by anti-angiogenesis targeted drugs,relieving the pain of patients and improving the quality of life of patients.
作者
张嫄爽
潘玉真
朱颖
ZHANG Yuan-shuang;PAN Yu-zhen;ZHU Ying(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;不详)
出处
《中国处方药》
2024年第3期143-146,共4页
Journal of China Prescription Drug
关键词
抗血管生成药
不良反应
恶性肿瘤
中药
Antiangiogenic agents
Adverse reactions
Malignant tumor
Chinese medicine
