摘要
目的探讨药物诱导睡眠后气道梗阻的危险因素研究。方法前瞻性选取2021年2月~2023年3月100例择期手术患者,入室后,于药物诱导睡眠成功后采用睡眠内镜观察患者气道梗阻情况,根据其结果将所有患者分为气道梗阻发生组和未发生组,收集两组一般资料及术中相关情况,采用多因素Logistic回归分析影响气道梗阻的因素,绘制ROC曲线并计算AUC。结果气道梗阻发生58例,未发生42例;多因素Logistic回归分析显示,年龄(OR=1.092,95%CI:1.011~1.180)、呼吸暂停次数(OR=7.584,95%CI:1.629~35.312)、低通气次数(OR=1.922,95%CI:1.257~2.940)、咪达唑仑用量(OR=1.284,95%CI:1.019~1.618)为气道梗阻发生危险因素(P<0.05);ROC曲线分析显示,年龄(AUC=0.764,95%CI:0.668~0.843);咪达唑仑用量(AUC=0.593,95%CI:0.491~0.691);低通气次数(AUC=0.880,95%CI:0.799~0.936);呼吸暂停次数(AUC=0.890,95%CI:0.811~0.943)。结论患者低通气次数、年龄、呼吸暂停次数以及药物诱导睡眠后咪达唑仑用量是气道梗阻的危险因素。
Objective To explore the risk factors of airway obstruction after drug induced sleep.Methods A prospective selection was conducted on 100 patients who underwent elective surgery in our hospital from February 2021 to March 2023.After entering the room and successfully inducing sleep with medication,sleep endoscopy was used to observe the airway obstruction status of the patients.Based on the results,all patients were divided into two groups:the group with airway obstruction and the group without airway obstruction.General data and intraoperative related information were collected from the two groups,and multiple factor Logistic regression analysis was used to analyze the factors affecting airway obstruction,draw ROC curve and calculate AUC.Results 58 cases of airway obstruction occurred,while 42 cases did not occur;Multivariate Logistic regression analysis showed that age(OR=1.092,95%CI:1.011~1.180),frequency of apnea(OR=7.584,95%CI:1.629~35.312),frequency of low ventilation(OR=1.922,95%CI:1.257~2.940),and dosage of midazolam(OR=1.284,95%CI:1.019~1.618)were risk factors for airway obstruction(P<0.05);Incorporating multiple influencing factors for ROC curve analysis showed that age(AUC=0.764,95%CI:0.668~0.843);dosage of midazolam(AUC=0.593,95%CI:0.491~0.691);hypoventilation frequency(AUC=0.880,95%CI:0.799~0.936);the number of apnea episodes(AUC=0.890,95%CI:0.811~0.943).Conclusion The frequency of low ventilation,age,frequency of apnea,and the dosage of midazolam after drug induced sleep are risk factors for airway obstruction in patients.
作者
郭星星
GUO Xing-xing(Guangdong Provincial People's Hospital Zhuhai Hospital(Zhuhai Jinwan Central Hospital),Zhuhai 519000,China.)
出处
《中国处方药》
2024年第3期11-14,共4页
Journal of China Prescription Drug
基金
珠海市科技计划项目(2H22036201210130PWC)
关键词
药物
诱导睡眠
气道梗阻
危险因素
Drugs
Inducing sleep
Airway obstruction
Risk factors
