摘要
目的探讨甲状腺癌组织中白细胞分化抗原147(CD147)及survivin表达及其与术后淋巴结转移的相关性。方法选取82例甲状腺癌患者作为研究对象,所有患者均行手术治疗,采集肿瘤标本及癌旁正常组织标本进行免疫组织化学检测,比较肿瘤标本及癌旁正常组织标本内CD147及survivin阳性表达差异;术后随访1年,记录淋巴结转移情况,依据淋巴结转移与否分为两组,收集两组患者年龄、性别、肿瘤分期、体质量指数、CD147表达、survivin表达、肿瘤直径等多方面资料,分别进行单因素、Logistic回归分析,获得影响甲状腺癌患者术后淋巴结转移的高危因素。结果肿瘤组织内CD147阳性率、survivin阳性率分别为73.17%、79.27%,高于癌旁正常组织,差异有统计学意义(P<0.05);82例患者术后随访1年,其中30例出现淋巴结转移,52例未出现淋巴结转移;两组肿瘤分期、CD147表达、survivin表达相比,差异有统计学意义(P<0.05);多因素显示,肿瘤分期Ⅲ期、CD147阳性表达、survivin阳性表达为影响甲状腺癌术后淋巴结转移的高危因素(P<0.05且OR>1)。结论CD147及survivin在甲状腺癌中存在较高阳性表达,且两者阳性表达为术后淋巴结转移的高危因素,应于早期开展该项检测,尽早识别危险因素,降低术后淋巴结转移风险。
Objective To investigate the correlation between the expression of leukocyte differentiation antigen 147(CD147)and survivin in thyroid carcinoma and postoperative lymph node metastasis.Methods 82 patients with thyroid cancer were selected as the study objects.All patients underwent surgical treatment.Tumor specimens and normal tissue specimens adjacent to the cancer were collected for immunohistochemical detection,and the positive expressions of CD147 and survivin in tumor specimens and normal tissue specimens adjacent to the cancer were compared;The patients were followed up for 1 year to record the lymph node metastasis of the 2 groups.They were divided into 2 groups according to whether the lymph node was metastatic or not.The data of age,sex,tumor stage,body mass index,CD147 expression,survivin expression,tumor diameter and other aspects of the 2 groups were collected.Single factor and logistic regression analysis were carried out to obtain the high-risk factors affecting the postoperative lymph node metastasis of thyroid cancer patients.Results The positive rates of CD147 and survivin in tumor specimens were 73.17%and 79.27%,which were higher than those in normal adjacent tissues(P<0.05);82 patients were followed up for 1 year,30 patients had lymph node metastasis,52 patients had no lymph node metastasis;There were significant differences in tumor stage,CD147 expression and survivin expression between the 2 groups(P<0.05);Multivariate analysis showed that tumor stageⅢ,positive expression of CD147 and survivin were the high risk factors for postoperative lymph node metastasis of thyroid cancer(P<0.05 and OR>1).Conclusion CD147 and survivin have high positive expression in thyroid carcinoma,and their positive expression is a high risk factor for postoperative lymph node metastasis.The detection should be carried out early to identify the risk factors as early as possible to reduce the risk of postoperative lymph node metastasis.
作者
李治洛
辛雅萍
LI Zhiluo;XIN Yaping(The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第4期562-565,共4页
The Practical Journal of Cancer
关键词
甲状腺癌
白细胞分化抗原147
淋巴结转移
相关性
Thyroid cancer
Leukocyte differentiation antigen 147
Lymph node metastasis
Relevance
