摘要
目的基于国家专利数据分析中药复方治疗进展期胃癌的临床用药规律。方法检索中国国家知识产权局专利检索及分析系统建库至2022年11月9日中药复方治疗胃癌公开专利,使用Excel2019、R4.1.2进行药物频次统计、性味归经分析、关联规则分析及聚类分析。结果共纳入专利280项,中药处方280首。高频药物包含甘草、白花蛇舌草、黄芪、茯苓、半枝莲、半夏、当归等,药性以寒、温为主,药味以苦、甘、辛味为主,有毒中药占8.97%,药物归经以肝经、肺经、胃经为主。强关联药物组合有党参+黄芪→白花蛇舌草,茯苓+甘草→白术,党参+甘草→白术,白术+茯苓→甘草等。核心组方为党参、黄芪、白术、茯苓、甘草、半枝莲、白花蛇舌草。聚类分析获得5类药物组合。结论国家专利复方治疗进展期胃癌核心处方以扶正祛邪为主要原则,扶正常用党参、白术、黄芪、茯苓、甘草等,祛邪常用半枝莲、白花蛇舌草、猕猴桃根等,针对血虚、血瘀、湿热、痰凝等不同辨证可选白芍、莪术、三七、延胡索、薏苡仁、半夏等药物。
Objective To analyze the clinical medication law of TCM compounds for the treatment of advanced gastric cancer based on the national patent data.Methods The public TCM compound patents for the treatment of advanced gastric cancer were searched from China National Intellectual Property Administration Patent Search and Analysis System from the establishment of the databases to Nov.9,2022.The correlation function in Excel2019 and R 4.1.2 software was used to perform frequency statistics,property and taste and meridian analysis,association rule analysis and clustering analysis on the compounds.Results A total of 280 patents and 280 prescriptions were obtained.Prescription analysis indicated that high-frequency drugs included Glycyrrhizae Radix et Rhizoma,Hedyotis diffusa,Astragali Radix,Poria,Scutellariae Barbatae Herba,Pinelliae Rhizoma,Angelicae Sinensis Radix etc.According to the meridian analysis of property and taste,the main properties of the medicine were cold and warm;the main tastes were bitter,sweet and pungent.Toxic traditional Chinese medicines accounted for 8.97%;the main meridians were liver,lung,and stomach.Association rule analysis showed that the medicinal combinations with strong associations includes Codonopsis Radix+Astragali Radix→Hedyotis diffusa,Poria+Glycyrrhizae Radix et Rhizoma→Atractylodis Macrocephalae Rhizoma,Codonopsis Radix+Glycyrrhizae Radix et Rhizoma→Atractylodis Macrocephalae Rhizoma,Atractylodis Macrocephalae Rhizoma+Poria→Glycyrrhizae Radix et Rhizoma,etc.The core prescriptions were Codonopsis Radix,Astragali Radix,Atractylodis Macrocephalae Rhizoma,Poria,Glycyrrhizae Radix et Rhizoma,Scutellariae Barbatae Herba,Hedyotis diffusa,and Hedyotis diffusa.Clustering analysis obtained 5 types of medicinal combinations.Conclusion The core prescriptions of TCM compounds for the treatment of advanced gastric cancer are based on strengthening the body and eliminating pathogenic factors.Codonopsis Radix、Atractylodis Macrocephalae Rhizoma、Astragali Radix、Poria、Glycyrrhizae Radi
作者
汪翰英
金甜
袁广众
张婷
王磊
毛丽娟
WANG Hanying;JIN Tian;YUAN Guangzhong;ZHANG Ting;WANG Lei;MAO Lijuan(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《中国中医药图书情报杂志》
2024年第2期36-40,共5页
Chinese Journal of Library and Information Science for Traditional Chinese Medicine
关键词
进展期胃癌
中药复方
国家知识产权局专利检索及分析系统
数据挖掘
advanced gastric cancer
TCM compound
China national intellectual property administration patent search and analysis system
data mining
