摘要
脓毒症是一种由感染引起的全身炎症反应综合征,发病率和病死率高。脓毒症诱导的肝损伤(sepsis-induced liver injury,SILI)是脓毒症诱发的多器官综合征的表现之一。目前针对SILI的治疗尚无推荐的药理干预措施,而中医药基于整体观及辨证论治理念治疗SILI,体现出多靶点、多通路的治疗特点,可通过干预炎性因子及炎症信号通路、抗氧化应激、抑制细胞凋亡等全面防治SILI。该文通过回顾总结中医药治疗SILI的实验研究,明确其致病机制和治疗特点,以期为研发或制备新药提供更多的思路和方向。
Sepsis is a systemic inflammatory response syndrome caused by infection,with high morbidity and mortality.Sepsis-induced liver injury(SILI) is one of the manifestations of sepsis-induced multiple organ syndrome.At present,there is no recommended pharmacological intervention for the treatment of SILI.traditional Chinese medicine(TCM),based on the holism and dialectical treatment concept,shows the therapeutic characteristics of multi-target and multi-pathway and can comprehensively prevent and treat SILI by interfering with inflammatory factors,inflammatory signaling pathways,and anti-oxidative stress and inhibiting apoptosis.This article reviewed the experimental studies on the treatment of SILI with TCM to clarify its pathogenic mechanism and therapeutic characteristics,so as to provide more ideas and directions for the development or preparation of new drugs.
作者
尹艳萍
牟菲
尹艳丽
赵瑾怡
龚蕊
张璐璐
陈锦仪
李旺廷
王婧雯
YIN Yan-ping;MU Fei∗;YIN Yan-li;ZHAO Jin-yi;GONG Rui;ZHANG Lu-lu;CHEN Jin-yi;LI Wang-ting;WANG Jing-wen(College of Life Sciences,Northwest University,Xi′an 710069,China;Department of Pharmacy,Xijing Hospital,Air Force Medical University,Xi′an 710032,China;Zhejiang Thermo Pharmaceutical Co.,Ltd.,Jinhua 321000,China;School of Pharmacy,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第4期884-893,共10页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81903837,81774190,72074218)。
关键词
脓毒症
肝损伤
致病机制
中药及其有效成分
研究进展
sepsis
liver injury
pathogenic mechanism
traditional Chinese medicine and its active components
research progress
