摘要
[目的]分析结肠癌(CC)组织中色素框同源物2(CBX2)蛋白与老年CC患者腹腔镜根治术后远处转移的关系及预测患者术后远处转移风险的价值。[方法]收集腹腔镜根治术治疗且完成3年随访的119例老年CC患者资料,患者均接受病理组织CBX2蛋白检测,病例资料、相关检查资料等完整;统计患者随访期间远处转移发生情况并分组,采集并比较患者相关基线资料、CBX2蛋白表达,重点分析CC组织中CBX2蛋白与老年CC患者腹腔镜根治术后远处转移的关系及预测患者术后远处转移风险的价值。[结果]119例患者随访3年有18例出现远处转移(转移组),转移率为15.13%;转移组TNM/T分期Ⅲ期比例、淋巴结转移比例、癌胚抗原(CEA)水平、糖类抗原199(CA199)水平、CBX2蛋白表达均高于未转移组,差异有统计学意义(P<0.05);组间其他基线资料比较差异无统计学意义(P>0.05);经Logistic回归分析结果显示,TNM/T高分期、淋巴结转移、CEA升高、CA199升高、CBX2蛋白过表达均可能是老年CC患者腹腔镜根治术后远处转移的风险因子(OR>1,P<0.05);绘制ROC曲线发现,CC组织中CBX2蛋白预测老年CC患者腹腔镜根治术后远处转移风险的AUC>0.800有一定预测价值。[结论]老年CC患者腹腔镜根治术后远处转移可能与组织中CBX2蛋白过表达有关,且CBX2蛋白对老年CC患者术后远处转移有一定预测价值。
[Objective]To analyze the relationship between chromobox homolog 2(CBX2)protein in colon cancer(CC)tissues and distant metastasis after laparoscopic radical resection in elderly CC patients,and its efficacy on predicting distant metastasis after operation.[Methods]The data of 119elderly patients with CC who underwent laparoscopic radical resection and completed 3years of follow-up from May 2016to May 2018were collected,CBX2protein in pathological tissues were detected,the general characters and related examination data were collected;the occurrence of distant metastasis in patients during the follow-up period was counted and divided into groups,related baseline data and CBX2protein expression were collected and compared,the relationship between CBX2protein in CC tissues and distant metastasis after laparoscopic radical resection and the efficacy on predicting the risk of distant metastasis were analyzed.[Results]Among the 119patients completed 3years of follow-up,18patients had distant metastasis,and the metastasis rate was 15.13%;the proportions of TNM/T stage III and lymph node metastasis,levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)and expression of CBX2protein in distant metastasis group were higher than those in non metastasis group,and the difference was statistically significant(P<0.05);there was no statistical significant difference in other baseline data between the two groups(P>0.05);through Logistic regression analysis,the results showed that high TNM/T stage,lymph node metastasis,elevated CEA,elevated CA199and overexpression of CBX2protein might be the risk factors of distant metastasis in elderly patients with CC after laparoscopic radical resection(OR>1,P<0.05);the ROC curve was drawn and showed that the AUC of CBX2protein in CC tissues for predicting the risk of distant metastasis in elderly patients with CC after laparoscopic radical resection was more than 0.800.which had certain predictive value.[Conclusion]The distant metastasis of elderly patients with CC after lap
作者
于鹏
地力木热提·艾买提
丁志翔
段绍斌
YU Peng;Dilimureti Aimaiti;DING Zhi-xiang;DUAN Shao-bin(Department of General Surgery,Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University/Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital,830011Urumqi,Xinjiang China)
出处
《临床消化病杂志》
CAS
2024年第1期1-6,共6页
Chinese Journal of Clinical Gastroenterology
基金
新疆维吾尔自治区自然科学基金(No:2018D01C283)。
关键词
结肠肿瘤
腹腔镜根治术
远处转移
色素框同源物2蛋白
预测
colon cancer
laparoscopic radical resection
distant metastasis
chromobox homolog 2protein
prediction
