摘要
光学基因组图谱(OGM)是一种新型非测序的遗传学分析技术,可高精度分析全基因组范围的结构变异,具有独特技术优势,并且技术流程相对简单,易于实施。近年来OGM在血液肿瘤基因组结构变异分析中的应用已经得到广泛验证和认可。越来越多的研究显示,OGM的应用可帮助改进血液肿瘤的遗传学诊断、预后分层和治疗指导。现结合第65届美国血液学会年会的报道对相关研究进展进行阐述。
Optical genome mapping(OGM)is a novel non-sequencing genetic analysis technology that enables high-precision analysis of structural variations across the entire genome.It possesses unique technical advantages,and its procedural simplicity makes it easy to implement.In recent years,the application efficacy of OGM technology in the analysis of genomic structural variations in hematologic malignancies has been widely validated and recognized.Increasing evidence indicates that the application of OGM technology can help improve the genetic diagnosis,prognostic stratification and treatment guidance of hematologic malignancies.This article draws upon pertinent reports from the 65th American Society of Hematology Annual Meeting to provide an overview of the progress in applying OGM technology for the precise diagnosis and treatment of hematologic malignancies.
作者
王彤
张阳
刘铭
刘红星
Wang Tong;Zhang Yang;Liu Ming;Liu Hongxing(Department of Laboratory Medicine,Hebei Yanda Lu Daopei Hospital,Langfang 065201,China;Precision Medicine Center,Beijing Lu Daopei Institute of Hematology,Beijing 100176,China)
出处
《白血病．淋巴瘤》
CAS
2024年第1期25-28,共4页
Journal of Leukemia & Lymphoma
基金
河北省医学科学研究课题计划(20220964)。
关键词
血液肿瘤
细胞遗传学
光学基因组图谱
基因组结构变异
Hematologic neoplasms
Cytogenetics
Optical genome mapping
Genomic structural variationi
