摘要
目的观察保胎灵胶囊联合醋酸阿托西班注射液治疗晚期先兆流产的临床效果。方法选取邯郸市妇幼保健院2020年3月—2021年12月100例晚期先兆流产患者进行研究,按随机抽签法分为对照组和治疗组,各50例。对照组给予醋酸阿托西班注射液,首次静脉注射6.75 mg(时间>1 min,0.9 mL/6.75 mg),继以5 mL/37.5 mg(共20 mL)溶于180 mL葡萄糖中静滴(24 mL/h,持续3 h),3 h后以8 mL/h静滴,直至达到宫缩抑制效果。治疗组在对照组基础上口服保胎灵胶囊,3粒/次,3次/d,持续2周。比较两组的临床疗效、症状改善时间、血清性激素水平和母婴结局。结果治疗后,治疗组总有效率较对照组高(P<0.05)。治疗组腰酸改善时间、腹痛改善时间和阴道出血停止时间较对照组短(P<0.05)。治疗后,两组血清人绒毛膜促性腺激素(hCG)、孕酮(P)、雌二醇(E2)水平均较治疗前升高(P<0.05),且治疗组血清性激素水平较对照组高(P<0.05)。治疗后,治疗组足月分娩例数高于对照组,自然流产例数低于对照组(P<0.05)。结论保胎灵胶囊联合醋酸阿托西班注射液治疗晚期先兆流产疗效确切,可改善患者临床症状,调节血清性激素水平,改善母婴结局。
Objective To observe the clinical effect of Baotailing Capsules combined with Atosiban Acetate Injection in treatment of advanced threatened abortion.Methods Women(100 cases)with advanced threatened abortion in Handan Maternal and Child Health Hospital from March 2020 to December 2021 were divided into control and treatment groups according to the random drawing method,and each group had 50 cases.Women in the control group were iv administered with Atosiban Acetate Injection,the first infusion was 6.75 mg(time>1 min,0.9 mL/6.75 mg),followed by 5 mL/37.5 mg(total 20 mL)dissolved in 180 mL glucose by intravenous drip(24 mL/h for 3 h),and 3 h later by intravenous drip at 8 mL/h until the contraction inhibition effect was achieved.Women in the treatment group were po administered with Baotailing Capsules on the basis of the control group,3 grains/time,three times daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical efficacies,symptom improvement time,serum sex hormone levels,and maternal and infant outcomes in two groups were compared.Results After treatment,the total effective rate of the treatment group was higher than that of the control group(P<0.05).The improvement time of lumbar acid,abdominal pain and vaginal bleeding in the treatment group were shorter than those in the control group(P<0.05).After treatment,the serum levels of hCG,P,and E2 in two groups were higher than before treatment(P<0.05),and the serum sex hormone levels in the treatment group were higher than those in the control group(P<0.05).After treatment,the number of full-term eliveries in the treatment group was higher than that in the control group,but the number of natural abortions was lower than that in the control group(P<0.05).Conclusion Baotailing Capsules combined with Atosiban Acetate Injection is effective in treatment of advanced threatened abortion,can improve clinical symptoms,adjust sex hormone levels,improve maternal and infant outcomes.
作者
郭利红
魏彩芬
王芳
沙晓星
董辉
GUO Lihong;WEI Caifen;WANG Fang;SHA Xiaoxing;DONG Hui(Department of Obstetrics,Handan Maternal and Child Health Hospital,Handan 056001,China;Department of Nursing,Affiliated Hospital of Hebei University of Engineering,Handan 056002,China;Department of Genetics,Handan Maternal and Child Health Hospital,Handan 056001,China)
出处
《现代药物与临床》
CAS
2024年第2期452-455,共4页
Drugs & Clinic
基金
河北省医学科学研究课题计划(20231932)。
