摘要
目的:系统评价桂枝加龙骨牡蛎汤治疗失眠症的临床有效性和安全性。方法:在国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库、Pubmed、Web of Science、Embase等网站检索建库至2022年3月28日发表的关于桂枝加龙骨牡蛎汤治疗失眠症的随机对照试验(RCT)文献。由2名研究员进行文献筛选、资料提取、偏倚分析后,运用RevMan5.3软件进行Meta分析。结果:最终纳入RCT文献共17篇,涉及1 395例患者。Meta分析结果显示,桂枝加龙骨牡蛎汤的治疗有效率高于对照组OR(95%CI)为3.93(2.61~5.90),匹兹堡睡眠质量指数量表(PSQI)总分下降高于对照组MD(95%CI)为-2.05(-2.72~-1.38)。结论:桂枝加龙骨牡蛎汤可有效提高失眠症治疗有效率,缓解相关症状。但受纳入研究质量影响,该研究结论还有待高质量临床研究验证。
Objective:To systematically evaluate the clinical efficacy and safety of Guizhi and Longgu Muli Decoction in the treatment of insomnia.Methods:Randomized controlled trial(RCT)literature about Guizhi and Longgu Muli Decoction about treating insomnia in Cochrane Library,Pubmed,Web of science,Embase,CNKI and CSPD,CCD and Chinese Biomedical Literature Database from the establishment of the databases to March 28,2022 were searched.Two researchers conducted literature screening,data extraction and bias analysis,and then conducted meta-analysis using RevMan5.3 software.Results:A total of 17 RCT articles were included,involving 1395 patients.Meta analysis results showed that the effective rate of Guizhi and Longgu Muli Decoction was higher than the control group OR(95%CI)3.93(2.61 to 5.90),and the total score of Pittsburgh Sleep Quality Index(PSQI)decreased more than the control group MD(95%CI)-2.05(-2.72 to-1.38).Conclusion:Guizhi and Longgu Muli Decoction can effectively improve the effective rate of insomnia treatment and relieve related symptoms.However,affected by the quality of the included study,the research conclusion needs to be verified by high-quality clinical research.
作者
刘巧云
覃雅君
廖慧
詹笑妍
杨志敏
徐碧云
LIU Qiaoyun;QIN Yajun;LIAO Hui;ZHAN Xiaoyan;YANG Zhimin;XU Biyun(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China)
出处
《世界睡眠医学杂志》
2024年第1期47-55,共9页
World Journal of Sleep Medicine
基金
国家中医药管理局“中医药循证能力提升项目”(国中医药科技中药便函[2023]24号)。
