摘要
目的研究精神分裂症患者联合采用氨磺必利、无抽搐电休克治疗(Modified Electroconvulsive Therapy,MECT)对心电图的影响。方法通过随机数表法将新乡医学院第二附属医院2020年1月—2022年10月收治的82例精神分裂症患者分成常规组和联合组。常规组41例予氨磺必利治疗,联合组在常规组治疗基础上加用MECT。比较两组治疗效果,治疗前、治疗2周与12周时临床症状改善效果,治疗前和治疗12周时心电图指标变化及不良反应。结果常规组总有效率(78.05%)低于联合组(98.12%),差异有统计学意义(P<0.05);两组治疗2周、12周时阳性与阴性症状量表(PANSS)评分均低于治疗前,且联合组低于常规组,同组治疗前后对比及组间对比均有统计学意义(P<0.05);常规组治疗12周时心率、P-R间期和QRs低于联合组,差异有统计学意义(P<0.05);两组不良反应相比无统计学意义(P>0.05)。结论对精神分裂症采用氨磺必利结合MECT治疗能增强疗效、改善症状且不良反应少,但容易导致心电图改变,临床治疗期间需加强心电图监测,以保证安全。
Objective To study the effect of amsulapride combined with modified electroconvulsive therapy(MECT)on electrocardiogram in patients with schizophrenia.Methods Totally 82 patients with schizophrenia admitted to our hospi-tal from January 2020 to October 2022 were divided into conventional group and combination group by random number ta-ble method.Forty-one patients in the conventional group were treated with amsulpiride,and the combined group was additionally treated with MECT.The therapeutic effects of the two groups were compared,the improvement of clinical symptoms before treatment,2 weeks and 12 weeks after treatment,the changes of electrocardiogram indexes and adverse reactions before treatment and 12 weeks after treatment.Results The total effective rate of routine group(78.05%)was lower than that of combined group(98.12%),and the difference was statistically significant(P<0.05).The positive and negative Symptom Scale(PANSS)scores in 2 and 12 weeks of treatment were lower than before treatment,and the combined group was lower than the conventional group,the comparison before and after treatment in the same group and the comparison between groups were statistically significant(P<0.05).After 12 weeks of treatment,the heart rate,P-R interval and QRs in the conventional group were lower than those in the combined group,and the differences were statistically significant(P<0.05).There was no statistical significance in adverse reactions between the two groups(P>0.05).ConclusionnAmsulpiride combined with MECT in schizophrenia can enhance efficacy,improve symptoms and have few side effects,but it is easy to cause electrocardiogram changes.Ecg monitoring should be strengthened during clinical treatment to ensure safety.
作者
张桂艳
杨勇锋
程德君
ZHANG Gui-yan;YANG Yong-feng;CHENG De-jun(Department of Electrophysiology,the Second Affiliated Hospital of Xinxiang Medical College,Henan Provincial Psychiatric Hospital,Xinxiang,Henan 452370,China;Physical Therapy Center,the Second Affiliated Hospital of Xinxiang Medical College,Henan Provincial Psychiatric Hospital,Xinxiang,Henan 452370,China;Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical College,Henan Provincial Psychiatric Hospital,Xinxiang,Henan 452370,China)
出处
《医药论坛杂志》
2024年第2期182-185,190,共5页
Journal of Medical Forum
关键词
心电图
无抽搐电休克
不良反应
氨磺必利
精神分裂症
Electrocardiogram
Modified electroconvulsive therapy
Adverse reaction
Amsulpiride
Schizophrenia
