摘要
肝脏在维持机体凝血和抗凝动态平衡中发挥重要调节作用。肝硬化患者抗凝与凝血的动态平衡很脆弱,会因凝血因子减少,血小板计数下降,纤溶亢进而增加出血风险,同时还会因血管性血友病因子、凝血因子Ⅷ升高,抗凝蛋白C、抗凝蛋白S降低,凝血酶生成潜力增加,抗纤溶成分的改变而形成血栓。本文对肝硬化凝血障碍的机制进行综述,以期对临床医生关于肝硬化患者的出血或血栓性疾病的预防和治疗提供帮助。
The liver plays an important regulatory role in maintaining the dynamic balance of coagulation and anticoagulation in the body.Such dynamic balance is fragile in patients with liver cirrhosis,and the risk of bleeding can be increased due to reductions in coagulation factors and platelet count and excessive fibrinolysis;meanwhile,thrombus can be formed due to the increases in von Willebrand factor and coagulation factorⅧ,the reductions in anticoagulant protein C and anticoagulant protein S,the increase in thrombin-generating potential,and alterations in antifibrinolytic components.This article reviews the mechanisms of coagulation disorder in liver cirrhosis,so as to help clinicians with the prevention and treatment of bleeding or thrombotic disorders in patients with liver cirrhosis.
作者
孙荣荣
贺娜
张粉娜
张心怡
王梓依
王辉
边娜娜
闫红林
SUN Rongrong;HE Na;ZHANG Fenna;ZHANG Xinyi;WANG Ziyi;WANG Hui;BIAN Nana;YAN Honglin(Department of Gastroenterology,The First Affiliated Hospital of Xi’an Medical College,Xi’an 710077,China;Graduate School of Xi’an Medical University,Xi’an 710021,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2024年第3期616-620,共5页
Journal of Clinical Hepatology
基金
陕西省教育科学“十三五”规划课题(SGH20Y1330)
佑安肝病传染病专科医疗联盟专项基金(LM202003)
陕西基础科学(化学、生物学)研究院2022年度基础科学研究计划项目(22JHQ091)。
关键词
肝硬化
血液凝固
出血
血栓形成
Liver Cirrhosis
Blood Coagulation
Haemorrhage
Thrombosis
