摘要
目的:探讨负压引流联合银离子水凝胶敷料治疗对2型糖尿病患者下肢皮肤慢性感染伤口愈合的影响。方法:选取2020年4月-2022年5月笔者医院收治的99例2型糖尿病下肢皮肤慢性感染伤口患者为研究对象,采用随机数字表法分为敷料组、负压引流组、联合组,各33例。敷料组采用银离子水凝胶外敷治疗,负压引流组采用伤口负压引流治疗,联合组采用负压引流联合银离子水凝胶敷料治疗。统计三组创面愈合时间、肉芽组织形成时间、上皮组织形成时间,比较三组治疗前、治疗7 d、14 d疼痛情况及治疗前、治疗7 d创面渗液血管内皮生长因子(Vascular endothelial growth factor,VEGF)、基质金属蛋白酶-9(Matrix metallo proteninases-9,MMP-9)、组织型金属蛋白酶抑制剂-1(Tissue inhibitor of metallo proteinase-1,TIMP-1)、血清白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor narcosis factor-α,TNF-α)、白细胞介素-8(Interleukin-8,IL-8)、超氧化物歧化酶(Superoxide dismutase,SOD)、硫代巴比妥酸法检测丙二醛(Malondial dehyde,MDA)、晚期蛋白氧化产物(Advanced oxidation protein products,AOPP)水平。结果:三组创面愈合时间、肉芽组织形成时间、上皮组织形成时间均联合组<负压引流组<敷料组(P<0.05);治疗7、14 d,三组VAS评分联合组<负压引流组<敷料组(P<0.05);治疗7 d,三组VEGF、TIMP-1水平较治疗前升高,且联合组>负压引流组>敷料组,MMP-9水平较治疗前降低,且联合组<负压引流组<敷料组(P<0.05);治疗7 d,联合组血清IL-8、TNF-α、IL-6水平低于负压引流组、敷料组(P<0.05);治疗7 d,联合组SOD水平高于负压引流组、敷料组,MDA、AOPP水平低于负压引流组、敷料组(P<0.05)。结论:负压引流联合银离子水凝胶辅料治疗能减少2型糖尿病下肢皮肤慢性感染伤口患者创面MMP-9含量,增加VEGF、TIMP-1含量,减轻炎症反应和氧化应激反应,有助于促进伤口愈合,减轻疼痛程
Objective To investigate the effect of negative pressure wound therapy combined with silver ionized hydrogel on wound healing in type 2 diabetic patients with chronic skin infections in the lower extremities. Methods Ninety-nine patients with chronic infected wounds in the lower limb skin of type 2 diabetes admitted to the author's hospital from April 2020 to May 2022 were selected for the study.They were divided into group A,group B and group C with 33 cases in each group by random number table method.Group A received silver ionized hydrogel,group B received negative pressure wound treatment,and group C received negative pressure wound treatment combined with silver ionized hydrogel.The wound healing time,granulation tissue formation time,and epithelial tissue formation time of the three groups were counted.The pain score of the three groups before treatment,7 days and 14 days after treatment were compared.The levels of vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9),tissue metalloproteinase-1(TIMP-1) and serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),Superoxide dismutase(SOD),malondialdehyde(MDA),and advanced oxidation protein products(AOPP) in wound exhalation were compared between the three groups before treatment and 7 days after treatment. Results The wound healing time,granulation tissue formation time,and epithelial tissue formation time of the three groups were combined group < negative pressure drainage group < dressing group(P<0.05).On treatment day 7 and 14,the VAS scores of the three groups were all lower than those of combined group < negative pressure drainage group < dressing group(P<0.05). After 7 days of treatment,the levels of VEGF and TIMP-1 in the three groups were higher than those before treatment,and the combined group > negative pressure drainage group > dressing group,and the level of MMP-9 was lower than that before treatment,and the combined group < negative pressure drainage group < dressing group(P<0.05). On the 7th day of tr
作者
谢银花
刘瑾
何润
XIE Yinhua;LIU Jin;HE Run(Wound Treatment Center,Mianyang Central Hospital,Mianyang 621000,Sichuan,China)
出处
《中国美容医学》
CAS
2024年第3期60-64,共5页
Chinese Journal of Aesthetic Medicine
关键词
负压引流
银离子水凝胶
2型糖尿病
慢性感染伤口
创面愈合
氧化应激反应
negative pressure wound treatment
silver ionic hydrogel
type 2 diabetes
chronic infected wound
wound healing
oxidativestressreaction
