摘要
目的:探讨酒依赖患者腹侧苍白球(VP)的体积变化及其与复饮的关系。方法:采用横断面与队列研究相结合的方法,选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)酒精依赖综合征诊断标准的患者33例,在停酒14~28 d内进行头部磁共振成像检查,采用自制调查问卷、临床机构酒精戒断症状评定量表(CIWA)、酒精使用障碍筛查量表(AUDIT)进行评估,采用自制随访问卷评估半年内治疗结局。比较酒依赖组与对照组,复饮组与非复饮组间VP体积。结果:酒依赖组的VP体积小于正常对照组[(1749±492)mm^(3) vs.(2116±189)mm^(3),P<0.05],复饮组的VP体积较非复饮组大[(1956±452)mm^(3) vs.(1555±458)mm^(3),P<0.05]。结论:酒依赖患者的VP可能参与病理性奖赏环路功能,并与复饮有关。
Objective:To investigate the volume change of ventral pallidum(VP)in alcohol-dependent patients(ADPs)and whether the volume of VP is related to rel apse.Methods:This study was a combi nation of cross-sectional and cohort study,which included 33 patients who met the diagnostic critenia for alcohol dependence syn-drome in the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-IV).All the ADPs received clinical questionnaires within 14-28 days of alcohol withdrawal,including a semi-structured questionnaire,the Clinical Institute Withdrawal Assessment(CIWA)and Alcohol Use Disorders Identification Test(AUDIT).The volumes of VP were measured by using magnetic resonance imaging(MRI).A self-made follow-up question-naire was used to assess post treatment outcome.The ADPs were divided into relapse group and abstinence group within the 6-month follow-up.The VP volume were compared between the ADPs and nommal controls,and relapse group and abstinence group.Results:The VP volumes were smaller in the ADPs than in the normal controls[(1749±492)mm^(3)vs.(2116+189)mm^(3),P<0.05].The VP volumes were larger in the relapse group than in the absti-nence group[(1956±452)mm^(3)vs.(1555±458)mm^(3),P<0.05].Conclusion:It suggests that the ventral pallidum in alcohol-dependent patients may participate in pathological reward circuit function,which is related to relapse.
作者
杨清艳
杨可冰
赵荣江
牛雅娟
于婷
范丰梅
范宏振
谭云龙
YANG Qingyan;YANG Kebing;ZHAO Rongjiang;NIU Yajuan;YU Ting;FAN Fengmei;FAN Hongzhen;TAN Yunlong(Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China)
出处
《中国心理卫生杂志》
CSCD
北大核心
2024年第4期301-305,共5页
Chinese Mental Health Journal
基金
北京市医院管理局临床医学发展专项经费资助(XMLX201834)
北京市属医院培育计划项目(PX2023072)。
关键词
酒依赖
复饮
皮质下
腹侧苍白球
磁共振成像
alcohol dependence
relapse
subcortical region
ventral pallidum
MRI
