摘要
癌症是全球第二大死因,对个人、家庭乃至社会有着重大的威胁。在癌症早期快速精确的确诊是减轻癌症致命影响的首要手段。随着生物传感器的发展,光学生物传感器受到广泛关注。这类传感器具有快速、实时、精确、灵敏度高、多元检测等优点,在癌症的临床诊疗工作中有巨大的应用潜力。从癌症标志物入手,讨论了用于癌症标志物检测现有生物传感器的优缺点。对光子晶体光纤工作原理和表面等离子体共振技术进行了介绍,结合近几年PCF-SPR传感器在生物学领域检测中的文献报道,重点综述了基于表面等离子体共振的光子晶体光纤传感器在癌症早期诊断方面的最新研究进展。最后,对PCF-SPR生物传感器在癌症检测领域中的进展进行了总结和展望。
Cancer is the second leading cause of death worldwide and poses a significant threat to individuals,families and society.Rapid and accurate diagnosis of cancer at an early stage is the primary means of mitigating the lethal effects of cancer.With the development of biosensors,optical biosensors have received widespread attention.This kind of sensor has the advantages of fast,real-time,accurate,high sensitivity and multiple detection,and has great application potential in the clinical diagnosis and treatment of cancer.This article discusses the advantages and disadvantages of existing biosensors for cancer marker detection,starting with cancer markers.The working principle of photonic crystal fiber and surface plasmon resonance technology are introduced,and the latest research progress of photonic crystal fiber optic fiber sensor based on surface plasmon resonance in early cancer diagnosis is reviewed,combined with the literature reports of PCF-SPR sensors in the field of biology in recent years.Finally,the progress of PCFSPR biosensors in the field of cancer detection is summarized and prospected.
作者
邸志刚
冯若楠
贾春荣
孔令丰
沈萌萌
张鸿斌
DI Zhigang;FENG Ruonan;JIA Chunrong;KONG Lingfeng;SHEN Mengmeng;ZHANG Hongbin(North China University of Science and Technology,Tangshan Hebei 063210,China)
出处
《激光杂志》
CAS
北大核心
2024年第2期7-12,共6页
Laser Journal
基金
河北省教育厅科学技术研究项目(No.ZD2021332)
河北省食品药品监督管理局科技计划重点项目(No.ZD2015016)。
