摘要
总结了全氟和多氟烷基物质(PFASs)的来源,综述了PFASs在生物体内的迁移转化行为及影响因素,并利用文献计量学方法对近38年PFASs的毒性研究进行了热点分析.结果表明PFASs的结构、生物组织中的酶活性、蛋白含量以及环境中的有机质含量与PFASs在生物体内的迁移和富集能力密切相关.PFASs毒性研究主要聚焦于不同环境介质和器官的毒性效应差异,研究方向由对动植物的毒性评价转变为人体健康风险预测.在此基础上,从个体、器官、生化和分子水平总结了PFASs毒性效应,提出关于PFASs的多层级毒性效应研究是未来的发展趋势,尤其是利用定量构效关系阐明生物毒性的层级效应是值得提倡的方法之一.展望了未来有关PFASs研究的发展方向,为阐明新污染物环境行为及开展相关毒理研究提供思路.
This paper summarizes the sources of per-and polyfluoroalkyl substances(PFASs),focuses on the migration and transformation behaviour of PFASs in organisms and the main factors,and provides a hotspot analysis of the toxicity of PFASs in the last 38years of research using bibliometric methods.The results showed that the structure of PFASs,the enzyme activity in and protein content in biological tissues,and the content of organic matter in the environment are closely related to the migration and enrichment ability of PFASs in organisms.The studies on the toxicity of PFASs mainly focused on the toxic effect differences between different environmental media and organs,and the direction of the studies changed from the toxicity evaluation of plants and animals to the prediction of human health risks.On this basis,the toxic effects of PFASs were summarized at the individual,organ,biochemical and molecular levels,and it was suggested that the study of multilevel toxicity of PFASs is the future development trend,especially the use of quantitative conformational relationships to elucidate the hierarchical effects of biotoxicity is one of the approaches worth advocating.Finally,the present paper looks forward to the future development of the research on PFASs,which will provide new ideas for elucidating the environmental behaviour of new pollutants and carrying out related toxicological studies.
作者
韩淼
李泽楷
许淋
李昭燕
文欣雨
侍卿
胡小婕
秦超
高彦征
HAN Miao;LI Ze-kai;XU Lin;LI Zhao-yan;WEN Xin-yu;SHI Qing;HU Xiao-jie;QIN Chao;GAO Yan-zheng(Institute of Organic Contaminant Control and Soil Remediation,Nanjing Agricultural University,Nanjing 210095,China)
出处
《中国环境科学》
EI
CAS
CSCD
北大核心
2024年第3期1638-1647,共10页
China Environmental Science
基金
国家自然科学基金资助项目(41925029,42107221)
国家重点研发计划项目(2023YFE0110800)
中央高校基本科研业务费专项资金资助项目(XUEKEN2023040)。
关键词
全氟和多氟烷基物质
迁移转化
毒性
per-and polyfluoroalkyl substances
migration and transformation
toxicity
