摘要
目的:探讨环磷腺苷葡胺联合美托洛尔治疗室性心律失常患者的效果。方法:选取2021年5月至2023年1月该院收治的80例室性心律失常患者进行前瞻性研究,按照随机数字表法将其分为对照组与研究组各40例。对照组采用酒石酸美托洛尔缓释片治疗,研究组在对照组基础上联用注射用环磷腺苷葡胺治疗。比较两组临床疗效、治疗前后心功能指标[左心室射血分数(LVEF)、左心室收缩期末内径(LVESD)、左心室舒张期末内径LVEDD]水平、心肌损伤标志物[肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)]水平、心率变异性指标[窦性心搏RR间期标准差(SDNN)、窦性心搏RR间期平均值标准差(SDANN)、相邻RR间期差值的均方根(RMSSD)]水平、血管内皮功能指标[内皮素-1(ET-1)、同型半胱氨酸(Hcy)]水平及不良反应发生率。结果:研究组治疗总有效率为90.00%(36/40),高于对照组的72.50%(29/40),差异有统计学意义(P<0.05);治疗后,研究组LVEF、SDNN、SDANN和RMSSD值均高于对照组,LVESD、LVEDD值均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组血清ET-1、Hcy、cTnI、CK-MB及BNP水平均低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为10.00%(4/40),低于对照组的32.50%(13/40),差异有统计学意义(P<0.05)。结论:环磷腺苷葡胺联合美托洛尔治疗室性心律失常患者能改善其心功能和心率变异性,抑制心室重构,促进心律恢复正常,还能减轻血管内皮功能、心肌组织损伤程度,降低不良反应发生率,效果优于单用美托洛尔治疗。
Objective:To investigate effects of Meglumine adenosine cyclophosphate combined with Metoprolol in treatment of patients with ventricular arrhythmia.Methods:A prospective study was conducted on 80 patients with ventricular arrhythmia admitted to the hospital from May 2021 to January 2023.According to the random number table method,they were divided into control group and study group,40 cases in each group.The control group was treated with Metoprolol tartrate sustained-release tablets,while the study group was treated with Meglumine adenosine cyclophosphate for injection on the basis of that of the control group.The clinical efficacy,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)]levels,the myocardial injury markers[cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB),brain natriuretic peptide(BNP)]levels,the heart rate variability indexes[standard deviation of NN intervals(SDNN),standard deviation of the average NN intervals(SDANN),root mean square successive differences between successive R-R interval(RMSSD)]levels,the vascular endothelial function indexes[endothelin-1(ET-1),homocysteine(Hcy)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 90.00%(36/40),which was higher than 72.50%(29/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the LVEF,SDNN,SDANN and RMSSD values of the study group were higher than those of the control group,the LVESD and LVEDD values were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum ET-1,Hcy,cTnI,CKMB and BNP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 10.00%(4/40),which was lower than 32.50%(13/40
作者
冯粉
FENG Fen(Second Ward of Cardiovascular Department of Anyang People’s Hospital No.6,Anyang 455100 Henan,China)
出处
《中国民康医学》
2024年第5期24-27,共4页
Medical Journal of Chinese People’s Health
关键词
环磷腺苷葡胺
美托洛尔
室性心律失常
血管内皮功能
心室重构
心肌损伤
Meglumine adenosine cyclophosphate
Metoprolol
Ventricular arrhythmia
Vascular endothelial function
Ventricular remodeling
Myocardial injury
