摘要
目的 探究垂体瘤手术病人发生医院感染的病原菌分布及危险因素。方法 回顾性分析2018年6月至2022年4月南阳市中心医院279例垂体瘤病人临床资料,观察医院感染发生情况,分析病原菌分布情况,采用logistic回归分析影响垂体瘤手术病人发生医院感染的危险因素。结果 279例垂体瘤手术病人,26例发生医院感染,发生率为9.32%;分离出病原菌29株,其中革兰阴性菌占55.17%,革兰阳性菌占41.38%,真菌1株占3.45%;logistic回归分析,结果显示,肿瘤长径≥1 cm、手术时间>1 h、术后留置引流管、抗菌药物使用时间>7 d是垂体瘤手术病人发生医院感染的独立危险因素(P<0.05)。结论 垂体瘤手术病人医院感染风险高,感染病原菌以革兰阴性菌为主,肿瘤长径≥1 cm、手术时间>1 h、术后留置引流管、抗菌药物使用时间>7d是发生医院感染的独立危险因素,临床上应针对危险因素制定有效的感染防控措施,减少医院感染。
Objective To explore the pathogenic distribution and risk factors of nosocomial infection in patients undergoing pituitary tumor surgery.Methods The clinical data of 279 patients with pituitary tumor admitted to Nanyang Central Hospital from June 2018 to April 2022 were retrospectively analyzed,the incidence of nosocomial infection was observed,and the distribution of pathogenic bac-teria was analyzed.Logistic regression analysis was used to analyze the risk factors of nosocomial infection in patients undergoing pitu-itary tumor surgery.Results Among the 279 patients,26 patients had nosocomial infection,with an incidence of 9.32%.Twenty-nine strains of pathogenic bacteria were isolated,of which 55.17%were Gram-negative bacteria,41.38%Gram-positive bacteria,and 1 fun-gus accounting for 3.45%.Logistic regression analysis results showed that tumor diameter equal or greater than 1 cm,operation time longer than 1 h,indwelling drainage tube after operation,and antibiotic use time longer than 7 d were independent risk factors for noso-comial infection in patients with pituitary tumor(P<0.05).Conclusions Patients undergoing pituitary adenoma surgery have high risk of nosocomial infection.Gram-negative bacteria are the main pathogenic bacteria.Tumor size equal to or greater than 1 cm,operation time longer than 1 h,indwelling drainage tube after operation,and antibiotic use time longer than 7 days are independent risk factors for nosocomial infection.Effective infection prevention and control measures should be formulated to reduce nosocomial infection.
作者
贾金曦
姚春旭
刘畅
王明国
JIA Jinxi;YAO Chunxu;LIU Chang;WANG Mingguo(The Third Ward of Neurosurgery Department,Nanyang Central Hospital,Nanyang,He'nan 473000,China;Department of Neurosurgery,Nanyang Second General Hospital,Nanyang,He'nan 473009,China)
出处
《安徽医药》
CAS
2024年第4期786-789,共4页
Anhui Medical and Pharmaceutical Journal
基金
河南省医学科技攻关计划联合共建项目(LHGJ20191470)。
关键词
垂体肿瘤
交叉感染
病原菌
影响因素
Pituitary neoplasms
Cross infection
Pathogenic bacteria
Influencing factor
