摘要
妊娠期高血糖包括孕前糖尿病、糖尿病前期和妊娠糖尿病,易导致多种不良妊娠结局的发生,然而高血糖状态及影响母子健康的分子机制尚不清晰。研究表明细胞衰老是在多种驱动因素作用下出现不可逆的细胞生长停滞现象,这种现象与机体疾病密切相关,不仅在损伤修复和肿瘤抑制等方面发挥作用,而且与糖尿病的发生发展相关。近年多项研究发现,高血糖可能通过多种途径诱导滋养细胞异常衰老,不同糖代谢状态和胎盘滋养细胞衰老互相影响,可能决定着妊娠糖尿病的发生发展和母胎结局,据此,本文主要对正常妊娠与胎盘滋养细胞衰老、妊娠期高血糖与胎盘滋养细胞异常衰老、胎盘滋养细胞衰老与不良妊娠结局等方面的研究进展进行综述,以期从新的视角认识妊娠期高血糖导致不良妊娠结局的分子机制。
Hyperglycemia in pregnancy,including pregestational diabetes mellitus,prediabetes mellitus,and gestational diabetes mellitus,is associated with a variety of adverse pregnancy outcomes.However,the status of hyperglycemia and the molecular mechanisms that influence maternal and fetal health are unclear.Cellular senescence has been shown to be an irreversible arrest of cell growth driven by a variety of drivers.This is closely related to the disease and plays a role not only in the repair of damage and tumor suppression,but also in the development of diabetes mellitus.A number of recent studies have revealed that hyperglycemia can induce abnormal trophoblast cell senescence in a variety of ways.Different glycemic metabolic states and placental trophoblast cell senescence may influence the development of gestational diabetes mellitus and maternal-fetal outcomes.Therefore,this paper reviews advances in normal pregnancy and placental trophoblast cells senescence,hyperglycemia in pregnancy and abnormal senescence of placental trophoblast cells,senescence of placental trophoblast cells and adverse pregnancy outcomes to understand the molecular mechanism of hyperglycemia in pregnancy from a new perspective.
作者
郑琳
李华萍
ZHENG Lin;LI Huaping(Department of Gynecology and Obstetrics,Shanghai Sixth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China;Department of Gynecology and Obstetrics,Jinshan Branch of Shanghai Sixth People's Hospital,Shanghai 200233,China)
出处
《中国优生与遗传杂志》
2024年第1期208-213,共6页
Chinese Journal of Birth Health & Heredity
基金
上海市科学技术委员会科研计划项目(19411961200)
上海市金山区专家团队工作站项目(jszjz2021018Y)。
关键词
妊娠期高血糖
细胞衰老
滋养细胞
妊娠结局
hyperglycemia in pregnancy
cellular senescence
trophoblast cell
pregnancy outcomes
