摘要
目的探讨中医内外结合疗法治疗脓毒症胃肠功能障碍的临床效果。方法选取医院急诊及住院部收治的62例脓毒症胃肠功能障碍患者为研究对象,按照入院顺序编号,随机分成观察组(n=31)和对照组(n=31)。对照组患者予以西医常规治疗,观察组在对照组基础上采用中医内外结合疗法,7d为1个疗程。比较两组临床疗效、炎症指标、胃肠功能障碍评分、腹内压、急性生理和慢性健康评分(APACHE II评分)、序贯器官功能衰竭评分量表(SOFA)以及肠道菌群水平。结果观察组疗效总有效率明显高于对照组(P<0.05)。观察组治疗后降钙素原(PCT)、白细胞计数(WBC)、C反应蛋白(CRP)水平明显低于对照组(P<0.05)。观察组治疗后胃肠功能障碍评分、腹内压水平明显低于对照组(P<0.05)。观察组治疗后胃肠功能障碍评分、腹内压水平明显低于对照组(P<0.05)。观察组治疗后APACHE II、SOFA评分明显低于对照组(P<0.05)。观察组治疗后双歧杆菌及乳酸杆菌计数明显多于对照组,肠球菌、肠杆菌计数明显少于对照组(P<0.05)。结论对脓毒症胃肠功能障碍患者采用中医内外合治法疗效良好,可有效改善患者胃肠功能,降低炎症因子水平,调节肠道菌群比例,缓解病情严重程度,改善预后。
Objective To explore the clinical effect of TCM internal and external therapy in the treatment of gastrointestinal dysfunction in sepsis.Methods A total of 62 patients with septic gastrointestinal dysfunction who were admitted to the emergency department and inpatient department of the hospital were selected as the research subjects.The patients in the control group were treated with conventional western medicine,and those in the observation group were treated with the combination of TCM internal and external treatments on the basis of the control group,and 7 days was a course of treatment.The clinical efficacy,inflammatory indexes,gastrointestinal dysfunction score,intra-abdominal pressure,acute physiology and chronic health score(APACHE II score),Sequential Organ Failure Assessment Scale(SOFA)and intestinal flora levels were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of procalcitonin(PCT),white blood cell count(WBC)and C-reactive protein(CRP)in the observation group were significantly lower than those in the control group(P<0.05).The scores of gastrointestinal dysfunction and intra-abdominal pressure in the observation group after treatment were significantly lower than those in the control group(P<0.05).The scores of gastrointestinal dysfunction and intra-abdominal pressure in the observation group after treatment were significantly lower than those in the control group(P<0.05).After treatment,the APACHE II and SOFA scores in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the counts of Bifidobacterium and Lactobacillus in the observation group were significantly higher than those in the control group,and the counts of Enterococcus and Enterobacter were significantly lower than those in the control group(P<0.05).Conclusion The combination of TCM internal and external treatment for sepsis patients with gastrointestinal dy
作者
徐航
茹凌
陈海华
黄夕夏
刘萍
XU Hang;RU Ling;CHEN Haihua;HUANG Xixia;LIU Ping(Baoshan Branch,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 210000,China;Shibei Hospital of Jing′an District,Shanghai 210000,China;Shanghai Public Health Clinical Center,Shanghai 210000,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第1期126-129,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
脓毒症
胃肠功能障碍
中医内外结合疗法
临床效果
sepsis
gastrointestinal dysfunction
TCM internal and external therapy
clinical effect
