摘要
目的调查国内多地区心外科围手术期人血白蛋白(HSA)临床应用情况,结合临床指南评价其应用合理性,为促进HSA的合理应用提供参考。方法回顾性收集2019年4—6月全国8家医院行心外科手术患者的病历资料,统计患者一般资料、HSA的用法用量、疗程、费用,用药前后血清白蛋白水平等信息,分析HSA的使用情况,建立相关评价标准对其应用的合理性进行评价。结果共纳入患者449例,HSA用药合理率为81.1%。用药疗程>2~5 d居多,HSA应用总量在50~99 g居多,用药目的主要为提高胶体渗透压、减轻渗出以改善间质水肿和术后扩充血容量。结论保证心外科围手术期HSA的合理应用,防止血液制品滥用需要引起临床的高度重视。
Objective To investigate the clinical application of perioperative human serum albumin(HSA)in cardiac surgery in multiple regions in China,and to evaluate the rationality of its clinical application in conjunction with the clinical guidelines,in order to provide a reference for promoting the rational application of HSA.Methods The medical records of patients who underwent cardiac surgery from April to June 2019 in eight hospitals across the country were retrospectively collected.The statistical information on patients’general information,the dosage,course of treatment,and cost of HSA,and the serum albumin level before and after medication was analyzed to evaluate the use of HSA.Relevant evaluation criteria were established,and the rationality of its medication was evaluated.Results Data from a total of 449 patients were included for analysis,the appropriate rate of medication was 81.1%.The course of medication was mostly>2-5 days and the total amount of HSA was mostly 50-99 g.The main purpose of medicaiton were improving colloid osmotic pressure,reducing exudation to improve interstitial edema,postoperative volume expansion.Conclusion Clinical attention should be paid to ensure the rational application of HSA in cardiac surgery during the perioperative period and prevent the abuse of blood products.
作者
潘文斐
于欢
党大胜
陈丽娟
李特
史天陆
黄帮华
李波霞
弓小雪
王莹
PAN Wenfei;YU Huan;DANG Dasheng;CHEN Lijuan;LI Te;SHI Tianlu;HUANG Banghua;LI Boxia;GONG Xiaoxue;WANG Ying(Department of Pharmacy,Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037,China;Department of Pharmacy,the Northern Theater Command General Hospital of Chinese PLA,Shenyang 110016,China;Department of Pharmacy,Tianjin Chest Hospital,Tianjin 300050,China;Department of Pharmacy,Fuwai Yunnan Cardiovascular Hospital,Kunming 650102,China;Department of Pharmacy,The First Affiliated Hospital of USTC(Anhui Provincial Hostipal),Hefei 230001,China;Department of Pharmacy,The First People's Hospital of Yunnan Province,Kunming 650032,China;Department of Pharmacy,The First Hospital of Lanzhou University,Lanzhou 730000,China;Institute of Clinical Pharmacy and Pharmacology,Jining First People’s Hospital,Jining 272000,Shandong Province,China)
出处
《药物流行病学杂志》
CAS
2024年第2期176-183,共8页
Chinese Journal of Pharmacoepidemiology
关键词
人血白蛋白
临床应用
回顾性调查
合理用药
Human serum albumin
Clinical application
Retrospective study
Rational drug use
