摘要
目的探讨定狂逐瘀汤联合奥氮平治疗急性脑梗死(acute cerebral infarction,ACI)所致精神障碍的临床效果。方法选取2021年8月至2023年3月南阳南石医院收治的ACI后出现精神障碍患者142例,中医辨证均为瘀血阻窍型,随机分为两组各71例,对照组给予奥氮平,观察组在此基础上加服定狂逐瘀汤,比较两组临床有效率、精神障碍程度、神经功能、生活质量及药物不良反应。结果观察组有效率(97.18%)高于对照组(77.46%)(P<0.05);观察组治疗2、4、8周PANSS评分为(66.85±5.28)、(59.28±5.76)、(51.48±5.18),低于对照组的(75.17±5.46)、(66.37±5.39)、(60.72±5.24)(P<0.05);观察组治疗2、4、8周TESS评分为(7.38±1.56)、(4.29±0.85)、(1.94±0.13),低于对照组的(9.15±2.32)、(5.89±0.94)、(2.85±0.36)(P<0.05);治疗后观察组NIHSS评分为(6.94±1.64),低于对照组的(8.14±1.65),治疗后观察组脑源性神经营养因子为(5.13±0.94)μg/L,神经生长因子为(163.93±15.15)μg/L,均高于对照组的(4.24±0.81)μg/L、(143.61±12.68)μg/L(P<0.05);观察组治疗后物质生活、躯体功能、心理功能、社会功能评分分别为(51.58±5.27)、(49.58±4.82)、(58.96±6.25)、(59.96±5.28),均高于对照组的(62.85±5.32)、(58.96±4.29)、(69.72±5.69)、(64.38±5.56)(P<0.05);观察组不良反应发生率(7.04%)低于对照组(21.13%)(P<0.05)。结论定狂逐瘀汤联合奥氮平治疗ACI所致精神障碍可提高临床疗效,改善精神症状与神经功能,降低药物不良反应,提高生活质量。
Objective To investigate the clinical effect of Dingkuang Zhuyu decoction combined with olanzapine on men⁃tal disorders caused by acute cerebral infarction(ACI).Methods Totally 142 patients with mental disorders after ACI treated from August 2021 to March 2023,all of whom were blood stasis type,were randomly divided into two groups with 71 patients in each group.The control group was given olanzapine,and the observation group was given Dingkuang Zhuyu decoction on the basis of this,and the clinical effective rate,degree of mental disorders,neurological function,quality of life and adverse drug reactions were compared between the two groups.Results The effective rate of observa⁃tion group(97.18%)was higher than that of control group(77.46%)(P<0.05).PANSS scores of observation group were(66.85±5.28),(59.28±5.76),(51.48±5.18)after 2,4 and 8 weeks of treatment,which were lower than those of control group(75.17±5.46),(66.37±5.39),(60.72±5.24)(P<0.05).The TESS scores of the obser⁃vation group at 2,4 and 8 weeks of treatment were(7.38±1.56),(4.29±0.85)and(1.94±0.13),which were lower than those of the control group(9.15±2.32),(5.89±0.94)and(2.85±0.36)(P<0.05).After treatment,the NIHSS score of the observation group was(6.94±1.64),which was lower than that of the control group(8.14±1.65),the brain-derived neurotrophic factor and nerve growth factor were(5.13±0.94)μg/L and(163.93±15.15)μg/L respectively.It was higher than that of control group(4.24±0.81)μg/L and(143.61±12.68)μg/L(P<0.05).After treatment,the scores of material life,physical function,psychological function and social function in the observation group were(51.58±5.27),(49.58±4.82),(58.96±6.25)and(59.96±5.28),respectively,which were higher than those of control group(62.85±5.32),(58.96±4.29),(69.72±5.69),(64.38±5.56)(P<0.05).The incidence of adverse reactions in observation group(7.04%)was lower than that in control group(21.13%)(P<0.05).Conclusion Dingkuang Zhuyu Decoction combined with olanzapine in the treatment of mental
作者
熊飞
王义
席三赢
XIONG fei;WANG Yi;XI San-ying(Department of Clinical Psychology,Nanyang Nanshai Hospital,Nanyang,Henan 473000,China)
出处
《医药论坛杂志》
2023年第24期81-85,共5页
Journal of Medical Forum
关键词
定狂逐瘀汤
奥氮平
脑梗死
精神障碍
临床疗效
神经功能
生活质量
Dingkuang Zhuyu Decoction
Olanzapine
Cerebral infarction
Mental disorder
Clinical effect
Neural func⁃tion
Quality of life
