摘要
目的探讨代谢综合征(MS)与复发性急性胰腺炎(RAP)之间的相关性。方法回顾性收集2012年6月1日至2023年6月1日就诊于重庆医科大学附属第一医院的463例RAP患者(复发组), 以及计算机随机抽取463例同期就诊的未复发的急性胰腺炎患者(未复发组)的临床资料。复发组患者初发和复发急性胰腺炎均就诊于重庆医科大学附属第一医院。分析两组之间合并MS及其各组分[肥胖(体重指数≥25 kg/m^(2))、空腹血甘油三酯≥1.7 mmol/L、高血压、高血糖、空腹血高密度脂蛋白胆固醇(HDL-C)<1.04 mmol/L]患者占比的差异。统计学方法采用卡方检验。采用二元logistic回归分析影响AP复发的危险因素。结果复发组463例患者中, MS患者221例(47.7%), 肥胖患者276例(59.6%), 高血压患者223例(48.2%), 高血糖患者185例(40.0%), 空腹血甘油三酯≥1.7 mmol/L患者365例(78.8%)。未复发组463例患者中, MS患者95例(20.5%), 肥胖患者245例(52.9%), 高血压患者115例(24.8%), 高血糖患者92例(19.9%), 空腹血甘油三酯≥1.7 mmol/L患者301例(65.0%)。复发组中MS、肥胖、高血压、高血糖、空腹血甘油三酯≥1.7 mmol/L患者占比均高于未复发组, 差异均有统计学意义(χ^(2)=76.27、4.22、54.35、44.55、21.90, P<0.001、=0.040、<0.001、<0.001、<0.001), 复发组与未复发组空腹血HDL-C<1.04 mmol/L患者占比[68.5%(317/463)比65.4%(303/463)]比较差异无统计学意义(P>0.05)。二元logistic回归分析结果显示, 合并MS[OR=3.538, 95%置信区间(95%CI) 2.647~4.728]、高血压(OR=2.700, 95%CI 2.025~3.602)、高血糖(OR=2.228, 95%CI 1.633~3.039)、空腹血甘油三酯≥1.7 mmol/L (OR=1.757, 95%CI 1.276~2.421)增加AP反复发作的风险, 均有统计学意义(P<0.001、<0.001、<0.001、=0.001);肥胖不是AP复发的独立危险因素(OR=0.967, 95%CI 0.727~1.286, P=0.816)。结论合并MS、高血压、高血糖及空腹血甘油三酯≥1.7 mmol/L是AP反复发作的独立危险因素。
Objective To investigate the correlation between metabolic syndrome(MS)and recurrent acute pancreatitis(RAP).Methods From June 1,2012 to June 1,2023,463 patients with RAP(recurrent group)who visited the First Affiliated Hospital of Chongqing Medical University were retrospectively collected.The clinical data of 463 patients without RAP(non-recurrent group)during the same period were randomly selected.The patients in the recurrence group were treated at the First Affiliated Hospital of Chongqing Medical University for both initial acute pancreatitis and RAP.The differences in the proportion of patients combined with MS and its components(obesity(body mass index≥25 kg/m^(2)),fasting blood triglyceride(TG)≥1.7 mmol/L,hypertension,hyperglycemia,fasting blood high-density lipoprotein cholesterol(HDL-C)<1.04 mmol/L)between the two groups were analyzed by Chi-square test.Binary logistic regression analysis was used to identify the risk factors of acute pancreatitis recurrence.Results Among the 463 patients in the recurrent group,there were 221 patients(47.7%)with MS,276 patients(59.6%)with obesity,223 patients(48.2%)with hypertension,185 patients(40.0%)with hyperglycemia,and 365 patients(78.8%)with fasting blood TG≥1.7 mmol/L.Among the 463 patients in the non-recurrence group,there were 95 patients(20.5%)with MS,245 patients(52.9%)with obesity,115 patients(24.8%)with hypertension,92 patients(19.9%)with hyperglycemia,and 301 patients(65.0%)with fasting blood TG≥1.7 mmol/L.The percentages of MS,obesity,hypertension,hyperglycemia,and fasting blood TG≥1.7 mmol/L of the recurrent group were all higher than those of the non-recurrent group,and the differences were statistically significant(χ^(2)=76.27,4.22,54.35,44.55,21.90;P<0.001,=0.040,<0.001,<0.001,<0.001).There was no statistically significant difference in the percentage of patients with fasting blood HDL-C<1.04 mmol/L between the recurrent group and the non-recurrent group(68.5%,317/463 vs.65.4%,303/463,P>0.05).The results of binary logistic regression analy
作者
沈娜思
谯敏
Shen Nasi;Qiao Min(Department of Gastroenterology,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《中华消化杂志》
CAS
CSCD
北大核心
2024年第1期38-43,共6页
Chinese Journal of Digestion
关键词
代谢综合征
复发性急性胰腺炎
高血压
高血糖
甘油三酯
相关性
Metabolic syndrome
Recurrent acute pancreatitis
Hypertension
Hyperglycemia
Triglyceride
Correlation
