摘要
目的回顾性探讨祛湿化瘀汤加减联合中药封包外敷治疗下肢深静脉血栓形成(DVT)时对患者静脉通畅效果、凝血功能、复发率的影响。方法选取医院2021年7月至2022年8月收治的下肢DVT患者病历资料,根据治疗方案将68例患者分为两组,各34例。两组均接受常规治疗,对照组接受中药封包外敷,研究组接受中药封包外敷联合祛湿化瘀汤内服。对比两组静脉通畅效果、血液流变学[高切全血黏度(H-WBV)、血浆黏度(PV)、红细胞比容(HCT)]、凝血功能[纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]、血清纤溶酶原激活物抑制剂1(serpine1)、血管性血友病因子(vWF)、Kruppel样转录因子(KLF2)水平及1 a复发率。结果研究组疗效优于对照组(P<0.05);治疗1、2周后,研究组H-WBV、PV、HCT、Fib、serpine1、vWF低于对照组,PT、APTT、KLF2高于对照组(P<0.05);研究组1 a复发率低于对照组(P<0.05)。结论祛湿化瘀汤联合中药封包外敷治疗下肢DVT效果显著,可能通过调节serpine1、vWF、KLF2等因子表达,改善凝血功能、血液流变学,防治血栓形成,降低复发率。
Objective To investigate the effects of Qushi Huayu decoction combined with external application of traditional Chinese medicine pack on venous patency,coagulation function and recurrence rate of patients with deep vein thrombosis(DVT).Methods The medical records of lower limb DVT patients admitted to the hospital from July 2021 to August 2022 were selected,and 68 patients were divided into two groups according to treatment plans,with 34 cases in each group.Both groups were given conventional treatment,based on this control group was given external application of traditional Chinese medicine pack,the study group was given external application of traditional Chinese medicine pack and Qushi Huayu decoction internal administration.The effect of venous patency,hemorheology[high cut whole blood viscosity(H-WBV),plasma viscosity(PV),hematocrit(HCT)],coagulation function[fibrinogen(Fib),activited partial thomboplastin time(APTT),prothrombin time(PT)],serum plasminogen activator inhibitor 1(serpine1),von Willebrand factor(vWF),Kruppel-like transcription factor(KLF2)levels and 1-year recurrence rate were compared between the two groups.Results The efficacy of the study group was better than that of the control group(P<0.05).After 1 week and 2 weeks of treatment,H-WBV,PV,HCT,Fib,serpine1 and vWF in the study group were lower than those in the control group,while PT,APTT and KLF2 were higher than those in the control group(P<0.05).The 1-year recurrence rate of the study group was lower than that of the control group(P<0.05).Conclusion Qushi Huayu decoction combined with external application of traditional Chinese medicine pack has a significant effect in the treatment of lower limb DVT,which may improve coagulation function and hemorheology,prevent thrombosis and reduce recurrence rate by regulating the expression of serpine1,vWF,KLF2 and other factors.
作者
任芬如
郑秀青
代雪娜
REN Fenru;ZHENG Xiuqing;DAI Xuena(Department of Peripheral Vascular,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2024年第4期731-735,共5页
Henan Medical Research
关键词
下肢深静脉血栓形成
祛湿化瘀汤
中药封包外敷
凝血功能
纤溶酶原激活物抑制剂
lower extremity deep vein thrombosis
Qushi Huayu decoction
external application of traditional Chinese medicine pack
coagulation function
plasminogen activator inhibitors
