摘要
Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.
基金
supported by the Natural Science Foundation of Beijing,China(7214223,7212027)
the Beijing Hospitals Authority Youth Programme(QML20210601)
the Chinese Scholarship Council(CSC)scholarship(201706210415)
the National Key Research and Development Program of China(2017YFC0908800)
the Beijing Municipal Health Commission(PXM2020_026272_000002,PXM2020_026272_000014)
the National Natural Science Foundation of China(82070293).
