摘要
线粒体铁蛋白(FtMt)是一种无内含子基因编码的铁蛋白,能通过调控细胞氧化应激、胞质铁的平衡,进而影响线粒体铁含量、线粒体功能、活性氧的产生和细胞GSH含量等。越来越多的证据表明FtMt参与神经退行性病变、缺血性脑卒中、创伤性脑损伤、不安腿综合征以及脑胶质瘤的发生、发展,本文总结了FtMt在多种神经系统疾病中发挥的不同作用,为探索多种神经系统疾病的机制研究提供参考。
Mitochondrial ferritin(FtMt)is a kind of ferritin without intron gene coding,which can affect mitochondrial iron content,mitochondrial function,production of reactive oxygen species and cell GSH content by regulating cellular oxidative stress and cytoplasmic iron balance.More and more evidence shows that FtMt is involved in the occurrence and development of neurodegenerative diseases,ischemic stroke,traumatic brain injury,restless leg syndrome and glioma.This paper summarizes the different roles of FtMt in a variety of neurological diseases,so as to provide reference for exploring the mechanism of a variety of neurological diseases.
作者
邵哲
郭大闯
孙榕
王帜
胡佳豪
彭浩
冯基高
SHAO Zhe;GUO Dachuang;SUN Rong;WANG Zhi;HU Jiahao;PENG Hao;FENG Jigao(Hainan Hospital Affiliated to Hainan Medical College\Hainan General Hospital,Haikou 570311,China;The Second Affiliated Hospital of Hainan Medical College,Haikou 570216,China)
出处
《海南医学院学报》
CAS
北大核心
2024年第5期390-394,共5页
Journal of Hainan Medical University
基金
海南省重点研发项目(ZDYF2021SHFZ111)。
关键词
线粒体铁蛋白
神经系统疾病
铁代谢
氧化应激
Mitochondrial ferritin
Nervous system disease
Iron metabolism
Oxidative stress
