摘要
目的探讨18氟标记前列腺特异性膜抗原-1007正电子发射计算机体层摄影(fluorine-18 prostate specific membrane antigen 1007-positron emission tomography/computed tomography,^(18)F-PSMA-1007 PET/CT)与多参数磁共振成像(multi-parameter magnetic resonance imaging,mp-MRI)单独及联合对前列腺癌(prostate cancer,PCa)的检测效能,并比较最大标准化摄取值(maximum standardized uptake value,SUV_(max))、表观弥散系数(apparent diffusion coefficient,ADC)、SUV_(max)/ADC、T1、T2、质子密度(proton density,PD)值与PCa病理分级的相关性。材料与方法回顾性分析我院2020年4月至2022年9月疑似PCa并拟行穿刺活检或手术的患者病例,最终50例患者被纳入研究,其中42例确诊PCa。按照国际泌尿病理协会(International Society of Urological Pathology,ISUP)分级共分为5组,包括中高级别组(分级≥4)25例和低级别组(分级1~3)17例,比较不同分组的SUV_(max)、ADC及SUV_(max)/ADC的差异。采用Spearman相关分析SUV_(max)、ADC、SUV_(max)/ADC、T1、T2、PD值之间的相关性及分别与ISUP分级的相关性。以病理为金标准,分析^(18)F-PSMA-1007 PET/CT与mp-MRI单独及联合对前列腺良恶性的检测效能。绘制受试者工作特征(receiver operating characteristic,ROC)并计算曲线下面积(area under the curve,AUC)、敏感度和特异度,评价SUV_(max)、ADC、SUV_(max)/ADC及联合参数诊断效能,通过DeLong检验比较AUC间的差异。结果PCa高级别组与低级别组的ADC值、SUV_(max)、SUV_(max)/ADC差异均有统计学意义(P均<0.001)。50例患者的ADC值与SUV_(max)呈负相关性(r=-0.516,P<0.05),42例确诊PCa患者的ADC值与ISUP分级呈负相关(r=-0.616,P<0.05),SUV_(max)、SUV_(max)/ADC与ISUP分级呈正相关(r=0.549、0.639,P均<0.05)。20例完成定量磁共振图像编译(magnetic resonance image compilation,MAGiC)序列患者T1、T2、PD值与ISUP分级无相关性(r=0.045、0.202、0.028,P均>0.05);T1、T2值与ADC值呈正相关(r=0.616,r=0.756,P均<
Objective:To explore the comparison of the detection efficacy of 18-fluoro-labeled prostate specific membrane antigen(^(18)F-PSMA-1007)positron emission tomography(PET)/computed tomography(CT)and multi-parameter magnetic resonance imaging(mp-MRI)alone and combined with prostate cancer(PCa)and the correlation between maximum standardized uptake value(SUV_(max)),apparent diffusion coefficient(ADC),SUV_(max)/ADC,T1,T2,proton density(PD)value and pathological grade of PCa.Materials and Methods:A retrospective analysis was made on 50 patients suspected of PCa who were scheduled to undergo biopsy or surgery in our hospital from April 2020 to September 2022,of which 42 cases were diagnosed with PCa.According to the International Society of Urological Pathology(ISUP),the patients were divided into 5 groups.According to ISUP classification,there were 25 cases in high grade group(≥4 grade)and 17 cases in low grade group(1-3 grade).The differences of SUV_(max),ADC and SUV_(max)/ADC in different grade groups were compared.Spearman correlation analysis was used to analyze the correlation among SUV_(max) value,ADC value,SUV_(max)/ADC,T1,T2,PD value and ISUP classification.Taking pathology as the gold standard,the efficacy of ^(18)F-PSMA-1007 PET/CT and mp-MRI alone or in combination in the detection of benign and malignant prostate was analyzed.The diagnostic efficacy of SUV_(max),ADC,SUV_(max)/ADC and combined parameters was evaluated by drawing receiver operating characteristic(ROC)and calculating the area under the curve(AUC),sensitivity and specificity,and the differences of AUC values were compared by DeLong test.Results:There were significant differences in ADC,SUV_(max),SUV_(max)/ADC between high-grade group and low-grade group(all P<0.001).Correlation analysis showed that there was a negative correlation between ADC and SUV_(max) in 50 cases of prostate diseases(r=-0.516,P<0.05),a negative correlation between ADC and ISUP in 42 cases of diagnosed PCa(r=-0.616,P<0.05),and a positive correlation between SUV_(max),SUV_(
作者
周云舒
陈晓华
陈志强
张若弟
刘世莉
王卓
张少茹
李鹏
李艳梅
ZHOU Yunshu;CHEN Xiaohua;CHEN Zhiqiang;ZHANG Ruodi;LIU Shili;WANG Zhuo;ZHANG Shaoru;LI Peng;LI Yanmei(School of Clinical Medicine,Ningxia Medical University,Yinchuan 750004,China;Department of Radiology,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China;Department of Radiology,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Department of Nuclear Medicine,General Hospital of Ningxia Medical University,Yinchuan 750004,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第2期71-76,96,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
宁夏回族自治区重点研发计划项目(编号:2019BEG03033)
宁夏自然科学基金(编号:2022AAC03472)。
关键词
前列腺癌
前列腺特异度膜抗原
弥散加权成像
最大标准化摄取值
表观弥散系数
磁共振成像
肿瘤分级
prostate cancer
prostate specific membrane antigen
diffusion weighted imaging
maximum standardized uptake value
apparent diffusion coefficient
magnetic resonance imaging
neoplasm grading
