摘要
足细胞损伤是糖尿病肾病(DN)发生的重要原因,而DN是造成终末期肾病的主要原因。目前对足细胞损伤机制研究有一定进展,但临床仍缺乏特异性治疗,难以根治。SIRT1、AMPK、mTOR在DN时均有不同程度的改变,其改变机制可能为相互协同或者拮抗。本文通过整理近年来针刺对3条信号通路的作用机制的研究,探讨针刺防治DN的可能性及作用机制,以期更好地服务临床。
Podocyte injury is an important cause of diabetes nephropathy(DN),and DN is the main cause of end-stage renal disease.At present,the research on the mechanism of podocyte injury has made some progress,but there is still a lack of specific treatment in clinic,which is difficult to cure.SIRT1,AMPK and m TOR have different degrees of changes in diabetes nephropathy,and the change mechanism may be synergistic or antagonistic.This paper discusses the possibility and mechanism of acupuncture in preventing and treating DN by sorting out the research on the mechanism of acupuncture on the three pathways in recent years,so that acupuncture can better serve the clinic and further develop the research on acupuncture.
作者
康文武
唐倩
郑灿磊
严江天
李奕宏
易璇
梁凤霞
KANG Wen-wu;TANG Qian;ZHENG Can-lei;YAN Jiang-tian;LI Yi-hong;YI Xuan;LIANG Feng-xia(College of Acupuncture-Moxibustion and Orthopedics-Traumatology,Hubei University of Chinese Medicine,Wuhan 430061;Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion,Wuhan 430061)
出处
《湖北中医药大学学报》
2024年第1期121-125,共5页
Journal of Hubei University of Chinese Medicine
基金
国家自然科学基金面上项目(项目编号:81774420)
国家中医药管理局岐黄工程项目(国中医药人教函[2018]284号)
针灸治未病湖北省协同创新中心/国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)重大、培育项目(项目编号:HBPCIC-2019-01)。
