摘要
目的 探讨脑脉解痉汤与动脉瘤性蛛网膜下腔出血(aSAH)患者脑血管血流动力学、血栓弹力图(TEG)及康复结局的临床相关性。方法 选取2020年1月至2022年12月中山市中医院收治的aSAH患者为研究对象,以患者是否使用脑脉解痉汤分为研究组和对照组。对照组行基础治疗联合尼莫地平,研究组术前予以基础治疗联合尼莫地平及脑脉解痉汤(1号)治疗,术后予以基础治疗联合尼莫地平及脑脉解痉汤(2号)治疗。比较两组治疗前后中医症状评分、脑血管血流动力学指标[收缩期峰流速(Vs)、平均血流速(Vm)、舒张期末峰流速(Vd)、脉动指数(PI)、阻力指数(RI)]及TEG参数[最大振幅(MA)、α角、凝血指数(CI)],通过格拉斯哥预后评分对两组患者短期预后进行评估。结果 研究共纳入160例aSAH患者,研究组85例、对照组75例。治疗后,研究组各项中医症状评分显著低于对照组(P <0.05),脑血管血流动力学指标均优于对照组(P <0.05),TEG参数显著低于对照组(P <0.05)。研究组整体短期预后优于对照组,且恢复良好的患者比例显著高于对照组(P <0.05)。结论 脑脉解痉汤用于aSAH患者具有较好的治疗效果,可改善脑血管血流动力学和TEG参数,缓解临床症状,从而改善患者短期预后。
Objective To investigate the clinical correlation of Naomai Jiejing decoction with cerebrovascular hemodynamics,thromboelastography(TEG)and rehabilitation outcome in patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods A total of 160 patients with aSAH admitted to Zhongshan Traditional Chinese Medicine Hospital from January 2020 to December 2022 were selected as the study objects,and were divided into study groupand control group according to whether the patients used Naomai Jiejing decoction.The control group was treated with basic therapy combined with nimodipine,the study group was treated with basic therapy combined with nimodipine and Naomai Jiejing decoction(No.1)before surgery,and was treated with basic therapy combined with Nimodipine and naomai Jiejing decoction(No.2)after surgery.Chinese medicine symptom score,cerebrovascular hemodynamics indexes[systolic peak velocity(Vs),mean blood velocity(Vm),end-diastolic peak velocity(Vd),pulsatile index(PI)and resistance index(RI)]and TEG parameters[maximum amplitude(MA),αangle and coagulation index(CI)]were compared between the two groups before and after treatment.Finally,the short-term prognosis of the two groups was evaluated by glasgow prognostic score,and the short-term prognosis of the two groups was compared.Results A total of 160 aSAH patients were included,with 85 in the study group and 75 in the control group.After treatment,the Chinese medicine symptom scores in the study group were significantly lower than those in the control group(P>0.05).After treatment,the indexes of cerebrovascular hemodynamics in the study group were better than those in the control group(P<0.05).After treatment,the TEG parameters in the study group were significantly lower than those in the control group(P<0.05).The overall prognosis of the study group was better than that of the control group,and the proportion of patients with good recovery was significantly higher than that of the control group(P<0.05).Conclusion Naomai Jiejing decoction has a good treatment effe
作者
王雪涛
林泽森
金丹
Xue-Tao WANG;Ze-Sen LIN;Dan JIN(Department of Neurosurgery,Zhongshan Traditional Chinese Medicine Hospital,Zhongshan 528400,Guangdong Province,China)
出处
《中国药师》
CAS
2023年第11期257-263,共7页
China Pharmacist
基金
中山市社会公益与基础研究项目(2020SYF03)。
