摘要
目的探究不同剂量瑞舒伐他汀对冠脉介入术后急性心肌梗死患者心室重构、心功能及血脂的影响。方法选取2021年4月至2023年4月在内蒙古医科大学附属医院行冠脉介入术的患者为研究对象,依据患者使用药物剂量分为低剂量组、中剂量组和高剂量组。各组患者均给予常规药物阿司匹林及氯吡格雷治疗,在此基础上低剂量组、中剂量组和高剂量组睡前分别服用5 mg、10 mg和20 mg的瑞舒伐他汀。治疗前后通过超声心动图评估患者的心功能,记录左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)和左室射血分数(LVEF);检测空腹静脉血清C反应蛋白(CRP)、基质金属蛋白酶-9(MMP-9)、脑钠素(BNP)以评估心室重构情况;检测空腹血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)以评估对血脂的影响;检测各组患者治疗前后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)以评估炎症反应。结果共纳入120例患者,每组40例。治疗后,3组患者LVEDD、LVESD、LVEDV、LVESV、LVEF、CRP、MMP-9、BNP、TC、TG、LDL-C、TNF-α和IL-6水平差异均有统计学意义(P<0.05)。相比低剂量组和中剂量组,高剂量组患者LVEDD、LVESD、LVEDV、LVESV、CRP、MMP-9、BNP、TC、TG、LDL-C、TNF-α和IL-6水平均显著降低,LVEF水平则显著升高(P<0.05)。结论不同剂量瑞舒伐他汀对冠脉介入术后急性心肌梗死患者心室重构、心功能及血脂的影响有一定的差异。相比常用的5 mg·d^(-1)和10 mg·d^(-1)剂量,使用20 mg·d^(-1)剂量瑞舒伐他汀预防心肌重塑改善心功能效果更佳。
Objective To explore the effects of different doses of rosuvastatin on ventricular remodeling,cardiac function and serum lipids in patients with acute myocardial infarction after coronary intervention.Methods Patients who received coronary intervention in The Affiliated Hospital of Inner Mongolia Medical University from April 2021 to April 2023 were selected as research subjects.The patients were divided into low-dose group,medium-dose group and high-dose group according to the drug dosage after admission.Patients in each group were treated with conventional drugs such as aspirin and clopidogrel.The low-dose group,the middle-dose group and the high-dose group took 5 mg,10 mg and 20 mg of rosuvastatin before going to bed on the basis of conventional drug treatment,respectively.Cardiac function was assessed by echocardiography before and after treatment,and left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),and left ventricular ejection fraction(LVEF)were recorded.Ventricular remodeling was assessed by fasting static serum C-reactive protein(CRP),matrix metalloproteinase-9(MMP-9),and brain natriuretic peptide(BNP).The fasting static serum total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)of patients in each group were detected to evaluate the influence on serum lipids.Serum tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were measured before and after treatment to evaluate the inflammatory response.Results A total of 120 patients were included,with 40 cases in each group.After treatment,the differences in levels of LVEDD,LVESD,LVEDV,LVESV,(LVEF),CRP,MMP-9,BNP,TC,TG,LDL-C,TNF-αand IL-6 were statistically significant among the three groups(P<0.05).Compared with low-dose and medium-dose groups,the levels of LVEDD,LVESD,LVEDV,LVESV,CRP,MMP-9,BNP,TC,TG,LDL-C,TNF-αand IL-6 in high-dose group were significantly decreased,while the levels of LVEF were
作者
宁玉珍
斯日古楞
白相君
双莲
Yu-Zhen NING;Siriguleng;Xiang-Jun BAI;Lian SHUANG(Department of Emergency Internal Medicine,Inner Mongolia Medical University Affiliated Hospital,Hohhot 010050,China;Second Ward of Geriatric Center,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)
出处
《中国药师》
CAS
2023年第10期90-96,共7页
China Pharmacist
基金
内蒙古医科大学面上项目(YKD2022MS077)。
关键词
瑞舒伐他汀
冠脉介入术
心室重构
心功能
血脂
Rosuvastatin
Coronary intervention
Ventricular remodeling
Cardiac function
Serum lipids
