摘要
乙型肝炎表面抗原(HBsAg)阴转(HBsAg<0.05 IU/ml)是现阶段肝炎领域的研究热点,达到HBsAg阴转的患者其肝脏相关的并发症明显减少。目前关于HBsAg阴转的研究较多,但临床中用于预测HBsAg阴转的指标仍偏少。基线低HBsAg定量及治疗过程中的动态下降是目前公认的预测HBsAg阴转的最佳指标,其他的因素如病毒基因型、治疗过程中的转氨酶升高、免疫细胞功能及细胞因子水平、宿主因素等均可以影响HBsAg阴转,现就HBsAg阴转的相关指标及潜在预测因子进行综述。
Hepatitis B surface antigen(HBsAg)negative seroconversion(HBsAg<0.05 IU/ml)is research hotspot in the field of hepatitis at this stage,and patients who achieve HBsAg negative seroconversion have significantly fewer liver-related complications.Presently,there are many studies with regard to HBsAg-negative seroconversion,but there are still relatively few indicators used in clinical practice to predict HBsAg-negative seroconversion.Low baseline HBsAg quantification and dynamic decline during treatment are currently recognized as the best indicators for predicting HBsAg-negative seroconversion.However,other factors such as viral genotype,elevated transaminases during treatment course,immune cell function and cytokine levels,and host factors can all influence HBsAg-negative seroconversion.This article reviews the relevant indicators and potential predictive factors for HBsAg-negative seroconversion.
作者
吴丽丽
高志良
Wu Lili;Gao Zhiliang(Department of Infectious Diseases,Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 501630,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2024年第2期186-192,共7页
Chinese Journal of Hepatology
基金
国家自然基金(82170612)
广州市科技计划重点项目(2023B01J1007)。
