摘要
目的 评估参七脉心通胶囊治疗急性缺血性卒中的临床疗效及对脂蛋白相关磷脂酶A2(Lp-PLA2)、超敏C反应蛋白(hs-CRP)的影响。方法 将2022年1—11月广州中医药大学附属广州中西医结合医院收治的72例急性缺血性卒中患者随机分为治疗组36例和对照组36例。2组均进行西医常规治疗,治疗组在此基础上给予参七脉心通胶囊口服,共治疗12周。比较2组患者治疗前后血清Lp-PLA2、hs-CRP水平及颈动脉内膜中层厚度、美国国立卫生研究院卒中量表(NIHSS)评分,统计2组治疗后临床疗效、颈动脉内膜中层厚度治疗效果、日常生活能力Barthel指数≥75分者占比、改良Rankin量表(mRS)评分≤2分者占比,并评价2组治疗安全性。结果治疗组和对照组各30例完成研究。治疗后,治疗组血清Lp-PLA2、hs-CRP水平及颈动脉内膜中层厚度、NIHSS评分均明显低于治疗前及对照组(P均<0.05),对照组仅血清Lp-PLA2水平和NIHSS评分明显低于治疗前(P均<0.05)。治疗组、对照组临床总有效率分别为86.7%(26/30)、63.3%(19/30),颈动脉内膜中层厚度治疗总有效率分别为66.7%(20/30)、40.0%(12/30),2组比较差异均有统计学意义(P均<0.05)。治疗组日常生活能力Barthel指数≥75分者和mRS评分≤2分者占比分别为63.3%(19/30)、73.3%(22/30),对照组分别为33.3%(10/30)、46.7%(14/30)(P<0.05),2组比较差异均有统计学意义(P均<0.05)。2组均未见明显不良反应发生。结论 参七脉心通胶囊能显著降低急性缺血性卒中患者血清血清Lp-PLA2、hs-CRP水平,缩小斑块,有助于神经功能康复及改善预后。
Objective It is to evaluate the clinical efficacy of Shenqi Mai-Xin-Tong capsule in the treatment of acute ischemic stroke and its effect on lipoprotein-associated phospholipase A2(Lp-PLA2)and high sensitive C-reactive protein(hs-CRP).Methods Seventy-two patients with acute ischemic stroke admitted to Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine from January to November 2022 were randomly divided into 36 patients in the treatment group and 36 patients in the control group.Both groups underwent conventional western medicine treatment,additionally,the treatment group was given Shenqi Mai-Xin-Tong capsule orally,totally treated for 12 weeks.The serum levels of Lp-PLA2 and hs-CRP,carotid intima-media thickness,and scores of National Institutes of Health Stroke Scale(NIHSS)of patients in the two groups before and after treatment were compared,the clinical efficacy and the efficacy of carotid intima-media thickness of the two groups were assessed,the percentage of patients with daily living ability Barthel index≥75,and the percentage of patients with modified Rankin Scale(mRS)scores≤2 were calculated,and the safety of treatment in the two groups was also evaluated.Results Both 30 cases in the treatment and control groups completed the study.After treatment,the serum levels of Lp-PLA2 and hs-CRP,carotid intima-media thickness and NIHSS scores in the treatment group were significantly lower than those before treatment and in the control groups(all P<0.05),and only serum level of Lp-PLA2 and NIHSS scores were significantly lower than those before treatment in the control group(both P<0.05).The total clinical effective rate of the treatment group and control group were 86.7%(26/30)and 63.3%(19/30),respectively,and the total effective rate of carotid intima-media thickness treatment was 66.7%(20/30)and 40.0%(12/30),respectively,and the differences between the two groups were statistically significant(all P<0.05).The percentage of patients with daily living ability Barthel index≥75 and that
作者
李洪涛
陈朝俊
LI Hongtao;CHEN Chaojun(Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China;Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510800,Guangdong,China)
出处
《现代中西医结合杂志》
CAS
2024年第1期22-27,共6页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
广东省中医药局科研项目(20213014)
广东省名中医传承工作室(20170122A149061)。
关键词
脂蛋白相关磷脂酶A2
超敏C反应蛋白
参七脉心通胶囊
急性缺血性卒中
lipoprotein-associated phospholipase A2
high sensitive C-reactive protein
Shenqi Mai-Xin-Tong capsule
acute ischemic stroke
