摘要
目的 探究听力正常孤独症谱系障碍(autism spectrum disorder,ASD)儿童的听性脑干反应(ABR)特征及各波潜伏期和波间期与ASD严重程度分级的关系。方法 (1)将55例(110耳)听力正常ASD儿童和月龄、性别相匹配的55例(110耳)典型发育(typical development,TD)儿童,按月龄分为≤24月龄(22耳)、25~36月龄(40耳)、37~48月龄(28耳)及>48月龄(20耳)四个亚组。比较听力正常ASD儿童与TD儿童的ABR潜伏期和波间期是否存在差异。(2)根据第五版精神障碍诊断与统计手册(DSM-V)将ASD儿童按照严重程度分级,探究听力正常ASD儿童ABR各波潜伏期和波间期与其严重程度分级是否相关。结果 (1)≤24月龄时,ASD与TD儿童ABR各波潜伏期及波间期差异均无统计学意义(P>0.05);(2)25~36月龄时,与TD儿童相比,听力正常ASD儿童波Ⅲ潜伏期及Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期显著延长;37~48月龄时波Ⅲ、Ⅴ潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期显著延长;>48月龄时波Ⅴ潜伏期及Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期显著延长(P<0.05);(3)ASD严重程度分级越高,ASD儿童波Ⅲ、Ⅴ潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期越长(P<0.05)。结论 自25月龄起听力正常ASD儿童与TD儿童的听觉脑干通路发育水平便显现差异,听力正常ASD儿童的听觉脑干发育水平显著落后于同龄TD儿童。听力正常ASD儿童的ABR波潜伏期和波间期与其严重程度分级相关。
Objective To investigate the effect of auditory brainstem response(ABR) in clinical detection and severity assessment of autism spectrum disorder(ASD) in children with normal hearing.Methods(1) A total of 55 autistic children(110 ears) with normal hearing and 55 children(110 ears) with typical development(TD) who did not differ in sex composition ratio and average monthly age were divided into four sub-groups according to age:≤24 months group(22 ears),25~36 months group(40 ears),37~48 months group(28 ears) and >48 months group(20 ears).The ABR latencies and interpeak latencies were compared between ASD children and age-matched TD children.(2) ASD children were graded by severity according to the Diagnostic and Statistical Manual of Mental Disorders(DSM-V),and the correlations between the ABR latencies and interpeak latencies in autistic children with normal hearing and the severity grading were studied.Results(1) No statistically significant differences in ABR wave latencies and interpeak latencies were found in autistic children with normal hearing under 24 months of age compared to age-matched TD children(P>0.05).(2) Compared with children with TD,autistic children with normal hearing at 25~36 months of age had significantly longer wave III latencies and the interpeak latencies of I-III and I-V;the significantly longer wave III,V latencies,the interpeak latencies of Ⅰ-Ⅲ,Ⅲ-Ⅴ and Ⅰ-Ⅴ in autistic children with normal hearing at 37~48 months of age.Autistic children with normal hearing in the >48 months group had significantly longer wave Ⅴ latencies and interpeak latencies of Ⅲ-Ⅴ,Ⅰ-Ⅴ than age-matched TD children(P<0.05).(3) The higher the ASD severity grading the longer the wave III and V latencies and the longer interpeak latencies of I-III,III-V,and I-V(P<0.05).Conclusion Differences in the level of auditory brainstem pathway development emerged at 25 months of age,and autistic children with normal hearing had significantly lower levels of auditory brainstem development than age-matched T
作者
林智涵
周欣
王雪彤
李颖
王雪瑶
金欣
郑之芃
周怡
史吉峰
刘海红
Lin Zhihan;Zhou Xin;Wang Xuetong;Li Ying;Wang Xueyao;Jin Xin;Zheng Zhipeng;Zhou Yi;Shi Jifeng;Liu Haihong(Department of Otolaryngology Head and Neck Surgery,Beijing Children s Hospital,Capital Medical University,National Center for Children's Health,Beijing,100045,China)
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2024年第2期118-123,共6页
Journal of Audiology and Speech Pathology
基金
北京市自然科学基金(7232059)
北京市科技新星计划交叉合作课题(20220484211)
高层次公共卫生技术人才建设专项(2022-3-016)
首都卫生发展科研专项项目(2022-1-2023)。
关键词
孤独症谱系障碍
听性脑干反应
儿童
Autism spectrum disorder
Auditory brainstem response
Children
