摘要
2020年全球癌症统计报告显示,消化系统恶性肿瘤发病率与死亡率均较高,但消化系统恶性肿瘤发生发展机制仍然未明确。维甲酸诱导蛋白(Retinoic acid-induced protein, RAI)是一类由维甲酸诱导的蛋白,与消化系统恶性肿瘤的增殖、侵袭、迁移关系密切,RAI系列蛋白在消化系统肿瘤中的表达水平与临床预后相关,过表达或敲低RAI蛋白可以影响消化系统恶性肿瘤对于靶向药物治疗的敏感性,RAI蛋白可能是消化系统肿瘤发生发展密切相关的特异性靶蛋白。本文就RAI蛋白在消化系统恶性肿瘤发生发展中的作用及相关机制等进行综述,为疾病早期诊断、治疗及预后评估提供一定的参考。
The Global Cancer Statistics Report in 2020 shows that the incidence and mortality of digestive system malignancies are high,but the mechanism is still unclear in the occurrence and development of digestive system malignancies.Retinoic acid-induced protein(RAI)is a kind of protein induced by retinoic acid,which is closely related to the proliferation,invasion and migration of digestive system malignant tumors.The expression of RAI series proteins in digestive system tumors is related to clinical prognosis.Overexpression or knockdown of RAI protein can affect the sensitivity of digestive system malignant tumors to targeted drug therapy.RAI protein may also be a specific target protein closely related to the occurrence and development of digestive system tumors.This article reviews the role and related mechanisms of RAI protein in the occurrence and development of malignant tumors in the digestive system,providing some references for early diagnosis,treatment and prognosis assessment of the disease.
作者
程锦(综述)
王玮(审校)
CHENG Jin;WANG Wei(College of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China;Department of Gastroenterology,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science)
出处
《实用肿瘤学杂志》
CAS
2023年第6期502-506,共5页
Practical Oncology Journal
基金
湖北省教育厅科研计划指导性项目(编号:B2020139)。
关键词
维甲酸诱导蛋白
消化系统恶性肿瘤
Retinoic acid-induced protein
Malignant tumors of the digestive system
