摘要
【目的】探讨新疆乌鲁木齐市社区中老年人骨骼肌质量与代谢综合征(MS)患病风险的相关性,为了解社区中老年居民骨骼肌质量与MS的关系提供理论依据。【方法】以2018年7月—2019年1月新疆多民族自然人群队列乌鲁木齐市1438名≥50岁社区居民为研究对象,使用问卷调查、体格检查、生物电阻抗分析(BIA)、实验室检测等方式收集数据。骨骼肌质量使用经体重校正的四肢骨骼肌质量指数(SMI)评估;MS的定义为至少存在以下之中的3项:腹部肥胖、高血压、高血糖、高三酰甘油和高低高密度脂蛋白胆固醇。将SMI分为Q_(1)~Q_(4)等4个四分位数组。应用趋势χ^(2)检验探讨SMI分级水平与MS之间的相关性;应用多因素logistic回归模型,分析较高SMI组(Q_(2)、Q_(3)、Q_(4))与参照组Q_(1)的MS患病风险的差异。【结果】共检出MS患者560人、患病率38.94%,其中男性代谢综合征患病率39.16%、女性患病率38.80%。男性SMI分级水平增加与MS患病率不相关(趋势性P>0.05);调整混杂因素后(模型4),SMI增加与MS患病率仍不相关(P_(趋势)=0.995),MS发生风险在SMI最低四分位数Q_(1)组和最高四分位数组Q_(4)(OR=1.01,95%CI:0.69~1.78)间不存在统计学差异。女性MS患病率随着SMI分级水平的增加逐渐下降(P_(趋势)<0.001);调整混杂因素后(模型4),SMI增加与MS患病率仍存在相关关系(P_(趋势)=0.005),且以SMI最低四分位数Q_(1)为参照组,Q_(2)(OR=0.63,95%CI:0.40~1.00)、Q_(3)(OR=0.56,95%CI:0.34~0.94)、Q_(4)(OR=0.42,95%CI:0.23~0.76)发生MS的风险均下降。【结论】骨骼肌质量增加可能有益于预防MS,尤其是女性中老年居民。考虑到我国老龄化加剧及MS与相关合并症的密切关系,管理骨骼肌质量可能有助于预防MS及潜在合并症。
[Objective]To explore the correlation between skeletal muscle mass and metabolic syndrome(MS)disease risk among middleaged and elderly community residents in Urumqi,and to provide a theoretical basis for understanding the relationship between skeletal muscle mass and MS among middle-aged and elderly community residents in China.[Methods]A total of 1438 community residents≥50 years old were selected as the research subjects from July 2018 to January 2019 in Urumqi.They were selected from a multi-ethnic natural population cohort in Xinjiang.Data were collected through questionnaires,physical examination,bioelectrical impedance analysis(BIA),laboratory tests,etc.Skeletal muscle mass was evaluated using the limb skeletal muscle mass index(SMI)corrected for body weight;MS was defined as it at least includes three of the following:abdominal obesity,hypertension,hyperglycemia,high triglycerides and low high-density lipoprotein cholesterol.SMI was divided into four quantile arrays of Q_(1)‒Q_(4).Trendχ^(2) test was applied to explore whether there was a correlation between SMI changes and MS.A multivariate logistic regression model was used to analyze whether there is a difference in the risk of MS between the higher SMI group(Q_(2),Q_(3),Q_(4))and the reference group Q_(1).[Result]A total of 560 MS patients were detected in this study,with a prevalence rate of 38.94%.Among them,the prevalence rate of MS was 39.16%in males and 38.80%in females.The increase in male SMI grading level is not correlated with the prevalence of MS(trend P>0.05);After adjusting for confounding factors(model 4),the increase in SMI was still not related to the prevalence of MS(P_(trend)=0.995).There was no statistical difference in the risk of MS between the lowest quartile group Q_(1) and the highest quartile group Q_(4)(OR=1.01,95%CI:0.69‒1.78).The prevalence of MS in women gradually decreased with the increase of SMI grading level(P_(trend)<0.001);After adjusting for confounding factors(model 4),there was still a correlation between the
作者
陈思敏
努尔比亚木·艾合提
沈静
晏师康
开地日艳·库日班江
彭星
阿卜杜乃比·吾普尔
戴江红
杨蕾
CHEN Simin;Nuerbiyamu Aiheti;SHEN Jing;YAN Shikang;Kaidiriyan Kuerbanjiang;PENG Xing;Abudunaibi Wupuer;DAI Jianghong;YANG Lei(School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang 830054,China)
出处
《上海预防医学》
CAS
2024年第1期40-46,共7页
Shanghai Journal of Preventive Medicine
基金
国家重点研发计划精准医学研究重点专项(2017YFC0907200,2017YFC0907201,2017YFC0907203)
新疆医科大学2022年博士科研启动基金项目。
关键词
骨骼肌质量
代谢综合征
中老年
社区
skeletal muscle mass
metabolic syndrome
middle aged and elderly
community
