摘要
目的:分析替罗非班联合双联抗血小板治疗在急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)中的应用效果。方法:选取2020年6月—2021年12月新沂市中医医院收治的60例AMI患者作为研究对象,随机分为两组,各30例。对照组采取PCI联合双联抗血小板治疗,观察组在对照组基础上联合替罗非班治疗。比较两组疗效。结果:观察组治疗总有效率高于对照组,室性心律失常发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组N末端脑钠肽前体(NT-proBNP)、脉压(PP)、QT离散度(QTD)、心率(HR)水平比较,差异无统计学意义(P>0.05);治疗后,两组NT-proBNP、PP、QTD、HR水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗前,两组左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、每搏输出量(SV)、二尖瓣舒张早期血流峰速度与二尖瓣环舒张早期运动峰速度比值(E/Em)水平比较,差异无统计学意义(P>0.05);治疗后,两组LVEF、SV水平高于治疗前,且观察组高于对照组,LVESD、LVEDD、E/Em水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:替罗非班联合双联抗血小板治疗在AMI患者PCI中的应用效果显著,可降低室性心律失常发生率,改善心血管功能及心功能。
Objective:To analyze the application effect of tirofiban combined with dual antiplatelet therapy in percutaneous coronary intervention(PCI) of acute myocardial infarction(AMI) patients.Methods:Sixty patients with AMI admitted to Xinyi Hospital of Traditional Chinese Medicine from June 2020 to December 2021 were selected as the study subjects.They were randomly divided into two groups,with 30 patients in each group.The control group was treated with PCI combined with dual antiplatelet therapy,and the observation group was treated with tirofiban on the basis of the control group.The efficacy of the two groups was compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the incidence of ventricular arrhythmia in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of N-terminal brain natriuretic peptide precursor(NT-proBNP),pulse pressure(PP),QT dispersion(QTD) and heart rate(HR) between the two groups(P>0.05).After treatment,the levels of NT-proBNP,PP,QTD and HR in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),stroke volume(SV),the ratio of early diastolic flow peak velocity of the mitral valve/early diastolic flow peak velocity of mitral valve annulus(E/Em) between two groups(P>0.05).After treatment,the levels of LVEF and SV in the two groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group,while the levels of LVESD,LVEDD and E/Em in the two groups were lower than those before treatment,and and t
作者
陆林
Lu Lin(Department of Cardiovascular Medicine,Xinyi Hospital of Traditional Chinese Medicine,Xinyi 221400,Jiangsu Province,China)
出处
《中国社区医师》
2024年第3期43-45,共3页
Chinese Community Doctors
关键词
急性心肌梗死
经皮冠状动脉介入术
替罗非班
室性心律失常
Acute myocardial infarction
Percutaneous coronary intervention
Tirofiban
Ventricular arrhythmia
