摘要
目的探讨喀什地区慢性阻塞性肺疾病(COPD)临床表型与肺功能指标的相关性。方法选取2021年3月至2022年1月喀什地区第一人民医院呼吸科收治的200例COPD患者为研究对象,依据2019版慢性阻塞性肺疾病全球倡议的划分标准,将入选COPD患者分成频繁急性加重(FE)组84例和非频繁急性加重(IFE)组116例,比较两组临床资料和肺功能指标的差异,并分析相关临床指标与肺功能的相关性。结果两组患者在性别、年龄、体重指数(BMI)、血压和吸烟史方面比较,差异无统计学意义(P>0.05)。FE组慢性阻塞性肺疾病评估测试(CAT)评分、改良英国医学研究会呼吸困难指数(mMRC)高于IFE组,差异有统计学意义(P<0.05)。FE组白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)高于IFE组,差异有统计学意义(P<0.05),第1秒用力呼气量(FEV_(1))、第1秒用力呼气量占预计值百分比(FEV_(1)%pred)、第1秒用力呼气量占用力肺活量百分比(FEV_(1)/FVC)低于IFE组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,COPD患者既往1年急性加重次数与CAT评分、mMRC评分、WBC、CRP、PCT水平呈轻中度正相关(P<0.05),与FEV_(1)、FEV_(1)%pred、FEV_(1)/FVC呈中度或显著负相关(P<0.05)。结论喀什地区FE与IFE两种临床表型COPD患者的临床特点存在明显异质性,前者肺功能往往更差,且COPD急性加重次数与肺功能下降紧密相关,应引起临床高度重视。
Objective To explore the correlation between clinical phenotypes and pulmonary function indicators in patients with chronic obstructive pulmonary disease(COPD)in Kashgar.Methods A total of 200 COPD patients admitted to the Respiratory Department of the First People’s Hospital of Kashgar from March 2021 to January 2022 were selected as the study subjects.According to the classification criteria of the 2018 Global Initiative for Chronic Obstructive Lung Disease,the selected COPD patients were divided into a frequent exacerbation(FE)group of 84 cases and an infrequent acute exacerbation(IFE)group of 116 cases.The differences in clinical data and pulmonary function indicators of two groups of COPD were compared,and the correlation between relevant clinical indicators and pulmonary function was analyzed.Results Gender,age,body mass index(BMI),blood pressure,and smoking history data between the two groups of patients showed no statistically significant differences(P>0.05).The FE group had higher scores on the COPD Assessment Test(CAT)and modified British Medical Research Council(mMRC)Dyspnea Scale compared to the IFE group,with statistically significant differences(P<0.05).The white blood cell count(WBC),C reactive protein(CRP),and procalcitonin(PCT)levels in the FE group were higher than those in the IFE group,with statistically significant differences(P<0.05).The forced expiratory volume in one second(FEV_(1)),the FEV_(1)%predicted(FEV_(1)%pred),and the ratio of FEV_(1)to forced vital capacity(FEV_(1)/FVC)were lower than those in the IFE group,with statistically significant differences(P<0.05).Spearman correlation analysis showed that the number of FEs in COPD patients in the past year had mild to moderate positive correlation with CAT scores,mMRC scores,and the levels of WBC,CRP and PCT(P<0.05),while it had moderate or significant negative correlation with FEV_(1),FEV_(1)%pred,and FEV_(1)/FVC(P<0.05).Conclusion There is significant heterogeneity in the clinical characteristics of COPD patients with FE and IFE clin
作者
沙吉旦·牙生
夏萍
SHAJIDAN Yasheng;XIA Ping(Health Management Center,the First People’s Hospital of Kashgar,Xinjiang,Kashgar 844000,China)
出处
《中国医药科学》
2024年第4期154-157,共4页
China Medicine And Pharmacy
关键词
慢性阻塞性肺疾病
频繁急性加重表型
非频繁急性加重表型
肺功能
相关性
Chronic obstructive pulmonary disease
Frequent exacerbation phenotype
Infrequent exacerbation phenotype
Pulmonary function
Correlation
