摘要
抗黑色素瘤分化相关基因5抗体阳性皮肌炎(MDA5+DM)是特发性炎性肌病的一种特殊类型,常隐匿地引起间质性肺病(ILD),甚至发展成快速进展型ILD,后者预后极差、病死率高。而且MDA5+DM-ILD的临床表现、疾病进展差异较大,在一定程度上限制了该疾病的早期诊断、早期治疗及预后判断。本文就MDA5+DM-ILD疾病中抗MDA5抗体的作用和该疾病的病因、发病机制、症状、治疗等临床特点的相关研究展开综述,重点阐述影响预后的相关因素及预测预后的模型,以期帮助临床医生了解该疾病特点,提高诊断水平,同时针对患者进行个体化治疗,改善患者预后,并对患者预后做出早期判断。
Anti-melanoma differentiation associated gene 5 antibody positive dermatomyositis(MDA5+DM) is a special type of idiopathic inflammatory myopathy,which often insidiously causes interstitial lung disease(ILD) and even develops into rapidly progressive ILD.The latter has a poor prognosis and a high mortality rate.Moreover,the clinical manifestations and disease progression of MDA5+DM-ILD vary greatly,to some extent limiting the early diagnosis,treatment,and prognosis estimation of the disease.This article reviews the research on the role of anti-MDA5 antibodies in MDA5+DM-ILD disease and the clinical characteristics of the disease,including its etiology,pathogenesis,symptoms,and treatment.The focus is on the factors that affect prognosis and the models for predicting prognosis,for clinical doctors to understand the characteristics of the disease,improve the diagnostic level,individualize treatment for patients,improve patient prognosis,and make early estimations on patient prognosis.
作者
吴华蔓
田茂良
邓治平
WU Huaman;TIAN Maoliang;DENG Zhiping(Department of Respiratory and Critical Care Medicine,Zigong First People’s Hospital,Sichuan,Zigong 643000,China)
出处
《中国医药科学》
2024年第3期45-49,共5页
China Medicine And Pharmacy
基金
四川省医学(青年创新)科研课题计划项目(S19046)。
关键词
间质性肺病
皮肌炎
抗黑色素瘤分化相关基因5抗体
临床特点
预后
Interstitial lung disease
Dermatomyositis
Anti-melanoma differentiation associated gene 5 antibody
Clinical characteristics
Prognosis
