摘要
目的了解新型冠状病毒感染(COVID-19)康复期IgG抗体水平及其与新型冠状病毒疫苗接种的关系。方法本研究为前瞻性队列研究。采用非随机抽样的方法,选取2023年2月至5月在清华大学第一附属医院呼吸与危重症医学科门诊和病房就诊的185例COVID-19康复者为研究对象。记录患者一般资料、发病时间、病情严重程度、接种新型冠状病毒疫苗情况。收集患者感染后6、8、10、12、14、16、18周不同时间点静脉血,采用半定量磁微粒化学发光法检测血清免疫球蛋白(Ig)G、IgM抗体水平。按照新型冠状病毒疫苗接种情况分为疫苗接种组(接种2剂次以上灭活疫苗,共130例)和疫苗未接种组(因各种原因未能接种疫苗,共55例)。将2组中>75岁康复者分别纳入亚组,疫苗接种亚组(18例)和疫苗未接种亚组(28例)。比较康复者整体、2组和2亚组各时间点的IgG、IgM抗体水平。结果185例COVID-19康复者中男80例,女105例;年龄62.0(40.5,75.0)岁;111例(60.00%)合并基础病。2组患者的性别比较差异无统计学意义(χ^(2)=0.03,P=0.874);疫苗未接种组年龄、合并基础病、重症或危重症比例均较疫苗接种组高,差异均有统计学意义(均P<0.01)。2亚组患者的性别、年龄、重症或危重症比例比较差异均无统计学意义(均P>0.05);疫苗未接种亚组合并基础病比例较疫苗接种亚组高,差异有统计学意义(χ^(2)=4.30,P=0.038)。全体康复者体内IgM抗体水平均为阴性。康复者整体IgG抗体水平在感染后第10周达到峰值,之后逐渐下降,于随访期末达最低值。疫苗接种组感染后第6、8、10、12、14、16、18周的IgG抗体水平均高于疫苗未接种组,差异均有统计学意义[157.9(73.4,240.0)比4.7(1.7,17.7),Z=2.36;132.0(75.3,213.1)比2.8(0.7,52.6),Z=3.77;137.7(79.9,227.0)比1.1(0.4,15.2),Z=4.51;134.5(81.4,211.9)比1.0(0.5,2.9),Z=3.49;92.4(68.9,112.9)比1.7(1.2,2.4),Z=2.84;61.2(33.3,108.7)比2.9(1.3,12.8),Z=3.45;57.1(32
ObjectiveTo measure the titer of immunoglobulin G(IgG)antibody during the recovery period from coronavirus disease(COVID-19)and their relationship with COVID-19 vaccine administration.MethodsIt was a prospective cohort study.One hundred and eighty-five patients recovered from COVID-19 admitted in the outpatient and inpatient,Department of Respiratory and Critical Care Medicine,the First Hospital of Tsinghua University from February 2023 to May 2023 were enrolled using the non-random sampling method.Baseline characteristics,onset time,severity,and COVID-19 vaccine administration details were recorded.Blood samples were collected at 6,8,10,12,14,16,and 18 weeks after the infection of COVID-19.Serum titers of IgG and IgM antibodies were measured by the semi-quantitative magnetic particle chemiluminescence method.Participants were categorized into vaccination group(received≥2 doses of vaccinations,n=130)and non-vaccination group(n=55).Participants over 75 years old and recovered from COVID-19 were subgrouped into vaccination subgroup(n=18)and non-vaccination subgroup(n=28).IgG and IgM titers were compared in the overall cohort,two groups and two subgroups.ResultsAmong 185 patients recovered from COVID-19,there were 80 males and 105 females with the mean age of 62.0(40.5,75.0)years.There were 111 cases(60.00%)of underlying diseases.There was no significant difference in gender between vaccination group and non-vaccination group(χ^(2)=0.03,P=0.874).The age and proportions of patients combined with underlying diseases,and severe or critically ill patients in the non-vaccination group were significantly higher than those in the vaccination group(all P<0.01).In subgroups,there were no significant differences in the gender,age and proportion of severe or critically ill patients(all P>0.05),but the proportion of patients with underlying diseases in the non-vaccination subgroup was significantly higher than that in the vaccination subgroup(χ^(2)=4.30,P=0.038).Negative IgM was detected in all participants.The IgG titer pe
作者
安树昌
刘国田
黄新
AGBO Sedine Marie Desiree Nina
逄晓莉
李兵
蔡善花
顾红岩
刘晓一
崔蓉
An Shuchang;Liu Guotian;Huang Xin;AGBO Sedine Marie Desiree Nina;Pang Xiaoli;Li Bing;Cai Shanhua;Gu Hongyan;Liu Xiaoyi;Cui Rong(Department of Respiratory and Critical Care Medicine,the First Hospital of Tsinghua University,Beijing 100016,China;School of Medicine,Tsinghua University,Beijing 100084,China;Department of Clinical Laboratory,the First Hospital of Tsinghua University,Beijing 100016,China)
出处
《国际呼吸杂志》
2024年第1期79-84,共6页
International Journal of Respiration
