摘要
目的分析认知训练同步经颅直流电刺激(tDCS)治疗卒中后认知碍(PSCI)患者工作记忆的疗效。方法选取2022年12月至2023年7月徐州市中心医院康复科和徐州市康复医院收治的60例PSCI患者为研究对象,采用随机数字表法分为伪刺激组、试验组A和试验组B,每组20例。3组患者均接受常规药物治疗和康复训练,伪刺激组在此基础上同时接受认知训练和tDCS伪刺激;试验组A同时接受认知训练和tDCS治疗;试验组B于认知训练结束2 h后接受tDCS治疗。认知训练与tDCS治疗均为5次/周,持续4周。在治疗前后分别采用蒙特利尔认知评估量表(MoCA)、数字广度测试(DST)、n-back任务(包括0-back、1-back)、改良Barthel指数(MBI)及定量脑电图[包括功率比指数(DTABR)、α波相对功率(αRP)及θ波相对功率(θRP)]比较3组患者的认知功能、工作记忆储存和信息编码能力、数字工作记忆、日常生活自理能力及脑神经功能。结果3组患者治疗前的MoCA、DST、0-back、1-back、MBI得分以及DTABR、αRP、θRP比较,差异均无统计学意义(均P>0.05)。3组患者治疗前后的MoCA、DST、0-back、1-back、MBI得分差值及DTABR、αRP、θRP差值比较,差异均有统计学意义(均P<0.05)。试验组A、B患者治疗前后的MoCA、DST、0-back、1-back、MBI得分差值及DTABR、αRP、θRP差值均高于伪刺激组,差异均有统计学意义(均P<0.05)。试验组A治疗前后的MoCA、DST、1-back得分差值及DTABR、θRP差值均高于试验组B,差异均有统计学意义(均P<0.05)。结论认知训练同步tDCS治疗在改善PSCI患者的工作记忆能力方面较两者分开进行更有优势。
Objective To explore the effect of cognitive training synchronized with transcranial direct current stimulation(tDCS)for the treatment of working memory in patients with post-stroke cognitive impairment(PSCI).Methods From December 2022 to July 2023,60 patients with PSCI admitted to the Rehabilitation Department of Xuzhou Central Hospital and Xuzhou Rehabilitation Hospital were selected as the research subject.Using the random number table method,patients were randomly divided into the pseudo stimulation group,experimental group A,and experimental group B,with 20 cases in each group.All three groups received conventional medication and rehabilitation training,on which the pseudo stimulation group received both cognitive training and tDCS pseudo stimulation therapy;experimental group A received both cognitive training and tDCS therapy;experimental group B received tDCS therapy 2 h after the end of cognitive training.Both cognitive training and tDCS treatment were 5 times per week for 4 weeks.Before and after treatment,the Montreal Cognitive Assessment(MoCA),Digital Span Test(DST),n-back task(including 0-back,1-back),Modified Barthel Index(MBI),and quantitative electroencephalogram[including delta theta/alpha beta ratio(DTABR),alpha relative power(αRP),andθrelative power(θRP)]were used to compare the cognitive function,working memory storage and information encoding ability,digital working memory,activity of daily living,and cranial nerve function of the three groups of patients.Results There was no statistically significant difference in MoCA scores,DST scores,0-back scores,1-back scores,MBI scores,DTABR,αRP andθRP among the three groups of patients before treatment(all P>0.05).The difference in MoCA,DST,0-back,1-back,and MBI scores and the difference in DTABR,αRP,andθRP before and after treatment of the 3 groups were statistically significant(all P<0.05).The difference in MoCA,DST,0-back,1-back,and MBI scores and the difference in DTABR,αRP,andθRP before and after treatment in the experimental groups A an
作者
周文欣
王世雁
顾成晨
晁静
欧香灵
巩尊科
Zhou Wenxin;Wang Shiyan;Gu Chengchen;Chao Jing;Ou Xiangling;Gong Zunke(The Second Clinical Medical School,Xuzhou Medical University,Xuzhou 221000,China;Graduate School,Bengbu Medical University,Bengbu 233000,China;Rehabilitation Department,Xuzhou Clinical School,Xuzhou Medical University,Xuzhou 221000,China)
出处
《神经疾病与精神卫生》
2024年第2期88-93,共6页
Journal of Neuroscience and Mental Health
基金
江苏省卫生健康委员会科研项目(K2019012)。
关键词
卒中
认知障碍
工作记忆
认知训练
经颅直流电刺激
脑电图
Stroke
Cognitive impairment
Working memory
Cognitive training
Transcranial direct current stimulation
Electroencephalography
