摘要
目的:观察人免疫球蛋白联合阿昔洛韦治疗病毒性脑炎患儿的效果。方法:选取2020年3月至2023年3月该院收治的76例病毒性脑炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各38例。对照组给予阿昔洛韦治疗,观察组在对照组基础上联合人免疫球蛋白治疗。比较两组临床疗效,临床症状改善时间,治疗前后炎性因子[降钙素原(PCT)、γ干扰素(INF-γ)、白细胞介素-6(IL-6)]水平、免疫功能指标[免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]水平,以及不良反应发生率。结果:观察组治疗总有效率为92.11%(35/38),高于对照组的73.68%(28/38),差异有统计学意义(P<0.05);观察组发热消失时间、惊厥消失时间、意识恢复时间和头晕、呕吐消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组PCT、INF-γ、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组IgG水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组IgM水平和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:人免疫球蛋白联合阿昔洛韦治疗病毒性脑炎患儿可提高临床疗效,促进临床症状恢复,减轻机体炎症反应,提高免疫功能,效果优于单纯阿昔洛韦治疗。
Objective:To observe effects of human immunoglobulin combined with Acyclovir in treatment of children with viral encephalitis.Methods:A prospective study was conducted on 76 children with viral encephalitis admitted to this hospital from March 2020 to March 2023.According to the random number table method,they were divided into control group and observation group,38 cases in each group.The control group was treated with Acyclovir,while the observation group was treated with human immunoglobulin on the basis of that of the control group.The clinical efficacy,the improvement time of clinical symptoms,the levels of inflammatory factors[procalcitonin(PCT),interferon-γ(INF-γ),interleukin-6(IL-6)],the immune function indexes[immunoglobulin M(IgM),immunoglobulin G(IgG)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.11%(35/38),which was higher than 73.68%(28/38)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,convulsion,dizziness and vomiting and the consciousness recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PCT,INF-γand IL-6 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The IgG levels of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the IgM level and incidence of adverse reactions between the two groups(P>0.05).Conclusions:Human immunoglobulin combined with Acyclovir in the treatment of the children with viral encephalitis can improve the clinical efficacy,promote the recovery of clinical symptoms,reduce
作者
袁霞
刘婉春
YUAN Xia;LIU Wanchun(Department of Pediatrics of the 990th Hospital of the Joint Logistics Support Force of the People’s Liberation Army,Zhumadian 463000 Henan,China)
出处
《中国民康医学》
2024年第4期104-106,126,共4页
Medical Journal of Chinese People’s Health
关键词
病毒性脑炎
阿昔洛韦
人免疫球蛋白
不良反应
炎性因子
Viral encephalitis
Acyclovir
Human immunoglobulin
Adverse reaction
Inflammatory factor
