摘要
目的探讨基底节区血管周围间隙扩大(EPVS)与轻型卒中颅外颈动脉硬化的相关性。方法选取2019-01—2023-03在芜湖市中医医院神经内科住院的轻型缺血性脑卒中患者120例,根据颈动脉彩超结果分为颈动脉硬化组(n=63)和无颈动脉硬化组(n=57),根据头颅MRI对基底节区EPVS分级并将患者分为轻度EPVS组(EPVS分级0~1级,n=61)和中重度EPVS组(EPVS分级2~4级,n=59)。比较颈动脉硬化组和无颈动脉硬化组的一般资料、实验室指标和基底节EPVS分级,Spearman相关性分析颈动脉内膜中层厚度(IMT)、Crouse斑块积分与基底节EPVS分级的相关性,单因素分析和多因素Logistic回归分析影响基底节EPVS严重度的危险因素。结果颈动脉硬化组基底节区EPVS等级高于无颈动脉硬化组(P<0.05),颈动脉IMT、Crouse斑块积分与基底节区EPVS等级正相关(r=0.575,P<0.001;r=0.481,P<0.001)。单因素分析和多因素Logistic回归分析得出颈动脉IMT、Crouse斑块积分是影响轻型卒中基底节区中重度EPVS的独立危险因素(P=0.046、0.009)。结论基底节区EPVS与轻型卒中患者颅外颈动脉硬化相关,提示两者可能存在相同的病理生理机制。
Objective To investigate the correlation between enlarged perivascular space(EPVS)in basal ganglia region and extracranial carotid atherosclerosis in mild stroke.Methods A total of 120 patients with mild ischemic stroke admitted to the Department of Neurology,Wuhu Hospital of Traditional Chinese Medicine from January 2019 to March 2023 were divided into the carotid arteriosclerosis group(n=63)and the non-carotid arteriosclerosis group(n=57)according to the results of carotid color ultrasound.The basal ganglion EPVS were graded according to the brain MRI.The patients were divided into mild EPVS group(EPVS level 0 to 1,n=61)and moderate to severe EPVS group(EPVS level 2 to 4,n=59).General datas,laboratory indexs and basal ganglia EPVS grade were compared between the carotid arteriosclerosis group and the non-carotid arteriosclerosis group.Spearman correlation analysis was performed to analyze the correlation between carotid intima-media thickness(IMT),Crouse plaque score and basal ganglia EPVS grade.Univariate analysis and multivariate Logistic regression analysis were performed to analyze the risk factors affecting the severity of basal ganglia EPVS.Results The grade of basal ganglia EPVS in the carotid atherosclerosis group was higher than that in the non-carotid atherosclerosis group(P<0.05).Carotid IMT and Crouse plaque score were positively correlated with EPVS grade in basal ganglia(r=0.575,P<0.001;r=0.481,P<0.001).Univariate analysis and multivariate Logistic regression analysis showed that carotid IMT and Crouse plaque score were independent risk factors for moderate and severe EPVS in basal ganglia region in patients with mild stroke(P=0.046,0.009).Conclusion EPVS in basal ganglia is associated with extracranial carotid atherosclerosis in patients with mild stroke.It suggesting that the two may have the same pathophysiological mechanism.
作者
高冕
杨雄杰
周守贵
GAO Mian;YANG Xiongjie;ZHOU Shougui(Wuhu Hospital of Traditional Chinese Medicine,Wuhu 241000,China)
出处
《中国实用神经疾病杂志》
2024年第3期337-342,共6页
Chinese Journal of Practical Nervous Diseases
基金
安徽省中医发展专项基金(编号:皖中医药发展秘〔2021〕18号)
芜湖市科学技术计划项目(编号:2021cg33)。
关键词
基底节
血管周围间隙扩大
轻型卒中
颈动脉硬化
相关性
Basal ganglia
Enlarged perivascular space
Mild stroke
Carotid atherosclerosis
Correlation
